Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Acute Oral Toxicity: REACH_LD50 > 5000 mg/kg bw | rat | - | #key study#
Acute Dermal Toxicity: REACH_LD50 > 5000 mg/kg bw | rat | - | #key study#
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- other: TRD Protocol No. 30, Book 1, p.389
- Principles of method if other than guideline:
- Single Oral Dose
Species Albino Male Rat
Condition: Animals fasted for 24 hours were dosed with the product as received. - GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
- Specific details on test material used for the study:
- No specific details on test material.
- Species:
- rat
- Strain:
- other: CF Nelson
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Species: Albino Male Rat
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Animals fasted for 24 hours were dosed with the product, as received.
- Doses:
- 5.0 g/kg
- No. of animals per sex per dose:
- Ten
- Control animals:
- no
- Details on study design:
- No further details specified.
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- One male died on day 3.
- Clinical signs:
- other: Signs of intoxication: Piloerection, lethargy, prostration, ataxia.
- Gross pathology:
- Gross autopsy on survivors found no visible lesions.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- LD50 greater than 5000 mg/kg
- Executive summary:
Single Oral Dose: Species Albino Male Rat
Condition: Animals fasted for 24 hours were dosed with the product as received.
Dosage: 5.0 g/kg
Died/dosed: 1/10
LD50 greater than 5.0 g/kg
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- > 5 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- other: TRD Protocol No. 31, Book 7, p.194
- Principles of method if other than guideline:
- Single Dermal Dose
Species Albino Male Rabbit
Condition: The product, as received, was held under an impervious cuff in continuous 24 hour contact with closely shaven skin. - GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
- Specific details on test material used for the study:
- No specific details on test material.
- Species:
- rabbit
- Strain:
- other: Albino
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Species: Albino Male Rabbit
- Type of coverage:
- other: Impervious cuff
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- The product, as received, was held under an impervious cuff in continuous 24 hour contact with closely shaven skin.
- Duration of exposure:
- 24 hours
- Doses:
- 5.0 g/kg
- No. of animals per sex per dose:
- Five
- Control animals:
- no
- Details on study design:
- No further details specified.
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- One male died on Day 7.
- Clinical signs:
- other: Signs of intoxication: Lethargy, soft feces, diuresis. Skin Irritation: Severe erythema and edema followed by eschar formation.
- Gross pathology:
- Gross autopsy on survivors found one animal had 2 yellow-white lesions of the left kidney.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- LD50 greater than 5000 mg/kg
- Executive summary:
Single Dermal Dose
Species: Albino Male Rabbit
Condition: The product, as received, was held under an impervious cuff in continuous 24 hour contact with closely shaven skin.
Dosage: 5.0 g/kg
Died/dosed: 1/5
LD50 greater than 5.0 g/kg
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- > 5 000 mg/kg bw
Additional information
Justification for classification or non-classification
The test item was submitted to acute oral toxicity testing in male rats at a dose of 5000 mg/kg. Observed clinical signs were piloerection, lethargy, prostation and ataxia. On day 3 one animal died.
The oral LD50 is therefore > 5000 mg/kg.
Dermal application of the test item at a dosage of 5000 mg/kg for 24 hours under an impervious cuff onto the shave skin of male rabbits resulted in severe erythema and edema formation. Observed clinical signs were lethargy, soft faeces and diuresis. One animal died on day 7. The oral LD50 is therefore > 5000 mg/kg.
Reaction mass of 2-(3a,4,5,6,7,7a-hexahydro-1H-4,7-methanoinden-5-yloxy)ethyl acrylate and 2-(3a,4,5,6,7,7a-hexahydro-1H-4,7-methanoinden-6-yloxy)ethyl acrylate does therefore not fulfil the classification criteria for acute oral and dermal toxicity and does not require classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
