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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1939

Materials and methods

Test guideline
Qualifier:
no guideline followed
Version / remarks:
Pre-Guideline- and Pre-GLP-Study.
Principles of method if other than guideline:
2 Experiments with 9 resp. 10 Animals were conducted. Dose level from ca. 15000 - 25000 mg/kg bw.
GLP compliance:
no
Remarks:
Pre-GLP-Study
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Test material form:
liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Doses:
Test 1: 15, 17.5, 20, 22.5 and 25 ml/kg
Test 2: 17.6, 18,6, 20.0, 21.4 and 22.6 ml/kg
No. of animals per sex per dose:
Test 1: 10
Test 2: 9
Control animals:
not specified

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
22 000 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion