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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Thirteen Cationic Ionophores: Their Acute Toxicity, Neurobehavioral and Membrane Effects
Author:
S. C. Gad, C. Reilly, K. Siino, F. A. Gavigan & G. Witz
Year:
2008
Bibliographic source:
DRUG AND CHEMICAL TOXICOLOGY, 8( 6 ) , 451-468 (1985)

Materials and methods

Principles of method if other than guideline:
15-Crown-5 was applied to rabbits and the sites were then scored by the Draize scale at 24, 48 and 72 hours after the removal of patches and a PDII (primary dermal irritation index) was calculated from these results.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
1,4,10,13-pentaoxacyclopentadecane
EC Number:
251-379-6
EC Name:
1,4,10,13-pentaoxacyclopentadecane
Cas Number:
33100-27-5
Molecular formula:
C10H20O5
IUPAC Name:
1,4,7,10,13-pentaoxacyclopentadecane

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Vehicle:
physiological saline
Amount / concentration applied:
0.5 mL
Duration of treatment / exposure:
24 h
Observation period:
72 h
Number of animals:
6

Results and discussion

In vivo

Results
Irritation parameter:
primary dermal irritation index (PDII)
Basis:
mean
Time point:
24/48/72 h
Score:
ca. 1.7
Reversibility:
not specified
Remarks on result:
other: individual animal data is not provided

Applicant's summary and conclusion

Conclusions:
Primary Dermal Irritation Index (PDII): 1.7