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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Thirteen Cationic Ionophores: Their Acute Toxicity, Neurobehavioral and Membrane Effects
Author:
S. C. Gad, C. Reilly, K. Siino, F. A. Gavigan & G. Witz
Year:
2008
Bibliographic source:
DRUG AND CHEMICAL TOXICOLOGY, 8( 6 ) , 451-468 (1985)

Materials and methods

Principles of method if other than guideline:
15-Crown-5 was applied to rabbits and the sites were then scored by the Draize scale at 24, 48 and 72 hours after the removal of patches and a PDII (primary dermal irritation index) was calculated from these results.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
1,4,10,13-pentaoxacyclopentadecane
EC Number:
251-379-6
EC Name:
1,4,10,13-pentaoxacyclopentadecane
Cas Number:
33100-27-5
Molecular formula:
C10H20O5
IUPAC Name:
1,4,7,10,13-pentaoxacyclopentadecane

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Vehicle:
physiological saline
Amount / concentration applied:
0.5 mL
Duration of treatment / exposure:
24 h
Observation period:
72 h
Number of animals:
6

Results and discussion

In vivo

Results
Irritation parameter:
primary dermal irritation index (PDII)
Basis:
mean
Time point:
24/48/72 h
Score:
ca. 1.7
Reversibility:
not specified
Remarks on result:
other: individual animal data is not provided

Applicant's summary and conclusion

Conclusions:
Primary Dermal Irritation Index (PDII): 1.7