1,4,10,13-pentaoxacyclopentadecane

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

publication

Title:

Thirteen Cationic Ionophores: Their Acute Toxicity, Neurobehavioral and Membrane Effects

Author:

S. C. Gad, C. Reilly, K. Siino, F. A. Gavigan & G. Witz

Year:

2008

Bibliographic source:

DRUG AND CHEMICAL TOXICOLOGY, 8( 6 ) , 451-468 (1985)

Materials and methods

Principles of method if other than guideline:

15-Crown-5 was applied to rabbits and the sites were then scored by the Draize scale at 24, 48 and 72 hours after the removal of patches and a PDII (primary dermal irritation index) was calculated from these results.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

1,4,10,13-pentaoxacyclopentadecane

EC Number:

251-379-6

EC Name:

1,4,10,13-pentaoxacyclopentadecane

Cas Number:

33100-27-5

Molecular formula:

C10H20O5

IUPAC Name:

1,4,7,10,13-pentaoxacyclopentadecane

Test animals

Species:

rabbit

Strain:

New Zealand White

Test system

Vehicle:

physiological saline

Amount / concentration applied:

0.5 mL

Duration of treatment / exposure:

24 h

Observation period:

72 h

Number of animals:

6

Results and discussion

In vivo

Results

Irritation parameter:

primary dermal irritation index (PDII)

Basis:

mean

Time point:

24/48/72 h

Score:

ca. 1.7

Reversibility:

not specified

Remarks on result:

other: individual animal data is not provided

Applicant's summary and conclusion

Conclusions:

Primary Dermal Irritation Index (PDII): 1.7