Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-654-9 | CAS number: 67-47-0
Vapour pressure
Administrative data
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15 May 2019 - 29 May 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Version / remarks:
- 2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Version / remarks:
- 2006
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- effusion method: vapour pressure balance
Test material
- Reference substance name:
- Reference substance 001
- Cas Number:
- 67-47-0
- Molecular formula:
- C6H6O3
- Reference substance name:
- Fructose
- EC Number:
- 200-333-3
- EC Name:
- Fructose
- Cas Number:
- 57-48-7
- Molecular formula:
- C6H12O6
- IUPAC Name:
- D-fructose
- Reference substance name:
- 1-(furan-2-yl)-2-hydroxyethanone
- Cas Number:
- 17678-19-2
- Molecular formula:
- C6H6O3
- IUPAC Name:
- 1-(furan-2-yl)-2-hydroxyethanone
- Reference substance name:
- Water
- EC Number:
- 231-791-2
- EC Name:
- Water
- Cas Number:
- 7732-18-5
- Molecular formula:
- H2O
- IUPAC Name:
- water
- Reference substance name:
- Sodium formate
- EC Number:
- 205-488-0
- EC Name:
- Sodium formate
- Cas Number:
- 141-53-7
- Molecular formula:
- CH2O2.Na
- IUPAC Name:
- sodium formate
- Reference substance name:
- Sodium nitrate
- EC Number:
- 231-554-3
- EC Name:
- Sodium nitrate
- Cas Number:
- 7631-99-4
- Molecular formula:
- HNO3.Na
- IUPAC Name:
- sodium nitrate
- Reference substance name:
- Glucose
- EC Number:
- 200-075-1
- EC Name:
- Glucose
- Cas Number:
- 50-99-7
- Molecular formula:
- C6H12O6
- IUPAC Name:
- D-glucose
- Reference substance name:
- Sodium acetate
- EC Number:
- 204-823-8
- EC Name:
- Sodium acetate
- Cas Number:
- 127-09-3
- Molecular formula:
- C2H4O2.Na
- IUPAC Name:
- sodium acetate
- Reference substance name:
- 2-furaldehyde
- EC Number:
- 202-627-7
- EC Name:
- 2-furaldehyde
- Cas Number:
- 98-01-1
- Molecular formula:
- C5H4O2
- IUPAC Name:
- 2-furaldehyde
- Reference substance name:
- Sodium 4-oxovalerate
- EC Number:
- 243-378-4
- EC Name:
- Sodium 4-oxovalerate
- Cas Number:
- 19856-23-6
- Molecular formula:
- C5H8O3.Na
- IUPAC Name:
- sodium 4-oxopentanoate
- Reference substance name:
- Formaldehyde
- EC Number:
- 200-001-8
- EC Name:
- Formaldehyde
- Cas Number:
- 50-00-0
- Molecular formula:
- CH2O
- IUPAC Name:
- formaldehyde
- Test material form:
- solid: crystalline
- Details on test material:
- freeze-dried material
Batch: 1808A-RO-C-I1-FD-Chg#3
Appearance Crystal / brown
Storage: Refrigerator (2 - 8 °C)
Expiring date: 31 December 2019
Constituent 1
impurity 1
impurity 2
impurity 3
impurity 4
impurity 5
impurity 6
impurity 7
impurity 8
impurity 9
impurity 10
- Specific details on test material used for the study:
- Storage Conditions: Dry, dark and cooled (2 °C to 8 °C)
Expiry Date: 2019-12-31
Results and discussion
Vapour pressureopen allclose all
- Key result
- Temp.:
- 20 °C
- Vapour pressure:
- 0.08 Pa
- Remarks on result:
- other: Calculated by extrapolation
- Key result
- Temp.:
- 25 °C
- Vapour pressure:
- 0.13 Pa
- Remarks on result:
- other: Calculated by extrapolation
- Key result
- Temp.:
- 50 °C
- Vapour pressure:
- 1.53 Pa
- Remarks on result:
- other: Calculated by extrapolation
Any other information on results incl. tables
The vapour pressure was measured in the temperature range from 27 to 58 °C. The measured vapour pressure values together with the measured temperatures are listed in the table below:
| No. | Temperature (°C) | Vapour pressure (Pa) |
| 1 | 27 | 0.18 |
| 2 | 32 | 0.27 |
| 3 | 37 | 0.46 |
| 4 | 42 | 0.70 |
| 5 | 47 | 1.11 |
| 6 | 53 | 2.04 |
| 7 | 58 | 3.22 |
The measured vapour pressures in the temperature range of 47 to 58 °C are slightly outside the measuring range (10-3 to 1 Pa) of the vapour pressure balance. Nevertheless, as the vapour pressure values above 1 Pa could be detected properly by the vapour pressure balance, the values can be used for the evaluation.
From the measured data points of the vapour pressure curve the constants A and B of the Antoine equation can be derived by regression of the data points to
A = 12.7988
B = -4076.15
C = 273.15.
Applicant's summary and conclusion
- Conclusions:
- The vapour pressure of the test item 5-(Hydroxymethyl)furfural was calculated for the temperatures 20, 25 and 50 °C by interpolation and extrapolation of the measured vapour pressure curve, according to Regulation EC No. 440/2008 Method A.4. Vapour Pressure and OECD Test Guideline 104 (2006). The vapour pressure was determined as follows:
0.08 Pa at 20°C, 0.13 Pa at 25°C, 1.53 Pa at 50°C. - Executive summary:
The vapour pressure of the test item 5-(Hydroxymethyl)furfural was calculated for the temperatures 20, 25 and 50 °C by interpolation and extrapolation of the measured vapour pressure curve, according to Regulation EC No. 440/2008 Method A.4. Vapour Pressure and OECD Test Guideline 104 (2006).
Temperature (°C) Vapour pressure (Pa) 20 0.08 25 0.13 50 1.53
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
