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Physical & Chemical properties

Vapour pressure

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vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Experimental dates: 04 to 06 January 2016
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
The study was conducted according to an internationally recognised method, and under GLP, but accuracy is limited by measuring range and extrapolation. The substance is adequately characterised. Therefore validation applies with restrictions.
according to guideline
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
23 Mar. 2006
according to guideline
EU Method A.4 (Vapour Pressure)
Version / remarks:
Regulation (EC) N°440/2008, as modified by Reg.(EC) No 761/2009
GLP compliance:
yes (incl. QA statement)
issued 8.4.2015
Type of method:
effusion method: Knudsen cell
Specific details on test material used for the study:
Storage conditions: The test item was stored in the test facility in a closed vessel at room temperature (20 ± 5 °C) protected from light.
Key result
25 °C
Vapour pressure:
3.76 Pa

Table 4.6/1: Vapour Pressures (Effusion Method)

 Experiment No.  T (°C)  T (K)  VP (Pa)  St. Dev (Pa)  RSD (%)
 1  30.0  303.2  5.788  0.1637  2.8
 2  40.0  313.2  13.37  0.7664  5.7
 3  50.0  323.2  28.50  0.6315  2.2

A graph with log VP vs. 1/T was plotted. Since the values were correlated by a linear relation, the data could be fitted by linear regression:

log (VP) = -3393.1 x (1/T) + 11.9555

The linear regression gave a correlation coefficient r of -0.9999, and a coefficient of Determination r2 of 0.9999.

For the test item, the following vapour pressures at 20 °C and at 25 °C were calculated from the regression equation:

Vapour pressure at 20 °C: 2.40 Pa

Vapour pressure at 25 °C: 3.76 Pa

Low volatility (based on volatility bands criteria for occupational exposure (Chesar / ECETOC TRA), << 500 Pa).
Executive summary:

The vapour pressure of test item was measured under GLP according to OECD 104 / EU A4 guideline, effusion method with Knudsen cell (weight loss).

Determinations were conducted at 30, 40 and 50°C, with triplicate measurements for each of the four cells.

The vapour pressure at 25°C of the test item was extrapolated from the regression as 3.76 Pa.

Description of key information

Low volatility.

Key value for chemical safety assessment

Vapour pressure:
3.76 Pa
at the temperature of:
25 °C

Additional information

A reliable experimental study, conducted according to a recognized OECD/EU method and under GLP, is available.

Despite (minor) restrictions due to technical inaccuracy, it is considered as key study, and the result is retained as key data.