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Physical & Chemical properties

Partition coefficient

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partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Test dates: July 24 to August 6, 2015
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
The study was conducted according to an internationally recognised method, and under GLP. No deviation affected the quality of the study. The substance is adequately characterised. Therefore full validation applies.
according to guideline
EU Method A.8 (Partition Coefficient - Shake Flask Method)
equivalent or similar to guideline
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
GLP compliance:
yes (incl. QA statement)
issued 05 March 2015
Type of method:
flask method
Partition coefficient type:
Specific details on test material used for the study:
- Physical state: Colourless translucent liquid
- Storage condition: Room temperature protected from direct sun light.
Analytical method:
gas chromatography
Key result
log Pow
Partition coefficient:
20 °C

ratio ratio 1:40 ratio 1:20 ratio 1:10
replicate vessel 1 2 1 2 1 2
log Kow 4.38 4.40 4.39 4.36 4.32 4.35
mass balance 101.5% 98.2% 103.0% 98,3% 94.0% 99.3%

Mean Log Pow and standard deviation = 4.37 ± 0.03

The observed interval within the six LogPow values was [4.32 - 4.40] and the validity criterion was fulfilled: The six LogPow values fell within a range of less than ± 0.3 units.

The pH of the water phase was measured as 7.1.

The substance has potential to bioaccumulate in the environment, according to CLP classification criteria for aquatic chronic toxicity (log Kow >4 ).
Executive summary:

The partition coefficient of the test substance was determined under GLP according to EU A.8 guideline, flask method.

Determinations were conducted in duplicate for three solvents ratio (1:40, 1:20 and 1:10, 2 replicates each), concentrations were measured using a GC-FID validated method. Individual results fulfilled the validity criteria for reproducibility, and mass balance was satisfactory, so the average value is retained.

The log Kow was determined to be 4.37 at 20°C (pH=7.1).

Description of key information

The data is relevant for classification in aquatic chronic toxicity hazard class, according to CLP criteria.

The substance has potential for bioaccumulation (log Kow >4).

Key value for chemical safety assessment

Log Kow (Log Pow):
at the temperature of:
20 °C

Additional information

A fully reliable experimental study, conducted according to a recognized EC method and under GLP, is available.

It is considered as a key study, and the result is retained as key data.