Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 601-489-9 | CAS number: 1176-81-4
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- other information
- Study period:
- 2002
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- GLP compliance:
- no
- Dissociating properties:
- yes
- No.:
- #1
- pKa:
- 14.2
- Remarks on result:
- other: calculated
- Remarks:
- concerning aliphatic hydroxy group
- Conclusions:
- Except for the aliphatic OH-group Fluocortolon-A-Acetat does not contain any functional group which can be protonated or deprotonated significantly in aqueous solution. Therefore, Fluocortolon-A-Acetat is to be considered as a neutral molecule in the pH range 2-10, which is of relevance for aqueous biological systems.
- Executive summary:
The chemical structure of Fluocortolon-A-Acetat does not contain any functional groups, which can be protonated or deprotonated in the biologically relevant range of pH 2 to 10 except for the aliphatic hydroxy group. The pKa calculation with the computer program ACD/pKa DB gave a value of 14.2 for the aliphatic hydroxy group. Therefore, the substance is to be considered as a neutral molecule in the pH range 2-10, which is of relevance for aqueous biological systems.
Reference
Except for the aliphatic OH-group the test substance does not contain any functional group which can be protonated or deprotonated significantly in aqueous solution. Therefore, the substance is to be considered as a neutral molecule in the pH range 2-10, which is of relevance for aqueous biological systems.
Description of key information
Except for the aliphatic OH-groups the Fluocortolon-A-Acetat does not contain any functional group which can be protonated or deprotonated significantly in aqueous solution. Therefore, the substance is to be considered as a neutral molecule in the pH range 2-10, which is of relevance for aqueous biological systems.
Key value for chemical safety assessment
Additional information
The pKa calculation with the computer program ACD/pKa DB ( Advanced Chemistry Development Inc., Toronto, Canada) gave a value of 14.2 for the aliphatic hydroxy groups. Therefore, the substance is to be considered as a neutral molecule in the pH range 2-10, which is of relevance for aqueous biological systems.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
