Registration Dossier
Registration Dossier
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EC number: 200-836-8 | CAS number: 75-07-0
Carcinogenicity
Administrative data
Description of key information
Increased incidences of tumours have been observed in inhalation studies on rats and hamsters exposed to acetaldehyde. In rats, there were dose-related increases in nasal adenocarcinomas and squamous cell carcinomas (significant at all doses). However, in hamsters, increases in nasal and laryngeal carcinomas were non-significant. All concentrations of acetaldehyde administered in the studies induced chronic tissue damage in the respiratory tract.
Key value for chemical safety assessment
Justification for classification or non-classification
Based on the data available, acetaldehyde is classified as carcinogenic Category 2, H351: Suspected of causing cancer according to 1272/2008/EEC (CLP) and R40: Limited evidence of a carcinogenic effect according to 67/548/EEC (DSD).
Additional information
These data and information are based on the sources of the IUCLID Dataset from 19 February 2000 published by the European Commission and the International Programme on Chemical Safety (IPCS) published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization (Environmental Health Criteria 167).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
