A mixture of cis- and trans-cyclohexadec-8-en-1-one

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2021-09-17 to 2021-09-22

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 123 (Partition Coefficient (1-Octanol / Water), Slow-Stirring Method)

Version / remarks:

2006

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

slow-stirring method

Partition coefficient type:

octanol-water

Analytical method:

gas chromatography

Key result

Type:

log Pow

Partition coefficient:

5.628

Temp.:

25 °C

pH:

6.7

Details on results:

See below

Partition Coefficient Results:

Replicate	Mean Test	Measured concentration		POW	Log POW
number	Duration [h]	in n-octanol [mg/L]	in aq. Phase [mg/L]		Single	Mean	SD ±	CV
1	67.45	25388	0.0536	473845	5.676	5.643	0.027	0.48
	72.70	23839	0.0537	444322	5.648
	89.24	22938	0.0529	433854	5.637
	94.53	21524	0.0528	407691	5.610
2	67.45	19298	0.0559	345109	5.538	5.600	0.042	0.75
	72.70	23792	0.0563	422830	5.626
	89.24	22504	0.0552	407734	5.610
	94.53	23008	0.0545	422016	5.625
3	67.45	22590	0.0549	411629	5.615	5.627	0.012	0.22
	72.70	23265	0.0541	429930	5.633
	89.24	22450	0.0539	416684	5.620
	94.53	22506	0.0514	437702	5.641
				Log POW mean		5.623
				log POW,Av		5.628
				slog POW,Av		0.007

Conclusions:

The partition coefficient (logPow) of test item was determined to be 5.628 at 25 °C and pH 6.8.

Executive summary:

The study on the partition coefficient of the test item was conducted according to OECD 123 (2006) and GLP. The test was performed employing the slow-stirring method at 25 ± 1 °C from three independent replicates (test vessels) with at least four sub-replicates (samples). A weighted average mean value was calculated according to the guideline. The concentrations of the dissolved material in two phases were analyzed via GC-MS method. Under The test conditions, the partition coefficient (logPow) of test item was determined to be 5.6328 at 25 °C and pH 6.8. 

Description of key information

A study on the partition coefficient of the item conducted according to OECD 123 (2006) and GLP is available. The test was performed employing the slow-stirring method at 25 ± 1 °C from three independent replicates (test vessels) with at least four sub-replicates (samples). A weighted average mean value was calculated according to the guideline. The concentrations of the dissolved material in two phases were analyzed via GC-MS method. Under The test conditions, the partition coefficient (logPow) of test item was determined to be 5.628 at 25 °C and pH 6.8. 

Key value for chemical safety assessment

Log Kow (Log Pow):

5.628

at the temperature of:

25 °C