Registration Dossier
Registration Dossier
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EC number: 617-251-2 | CAS number: 816431-72-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Mar - May 2006
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- 2001
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 4-{[(2-methoxyphenyl)formamido]sulfonyl}benzoyl chloride
- EC Number:
- 617-251-2
- Cas Number:
- 816431-72-8
- Molecular formula:
- C15H12ClNO5S
- IUPAC Name:
- 4-{[(2-methoxyphenyl)formamido]sulfonyl}benzoyl chloride
- Test material form:
- solid: bulk
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: tap water with 2% Cremophor EL
- Doses:
- 2000 mg/kg body weight (bw)
- No. of animals per sex per dose:
- 3 female rats
- Control animals:
- no
- Details on study design:
- dosing of 3 additional animals with the same dose (2000 mg/kg)
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- none
- Gross pathology:
- no findings
Any other information on results incl. tables
A dose of 2000 mg/kg body weight was tolerated by female rats without mortalities,
clinical signs, effects on weight gain and gross pathological findings.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- the test item is of low acute oral toxicity.
- Executive summary:
The single oral administration of the test substance (Amidchlorid, CAS 816431-72-8) to female rats at a dose of 2000 mg/kg was tolerated without any mortality. No compound-related clinical signs were observed and there were no macroscopic pathological signs.
The LD50 acute oral toxicity of Amidchlorid (CAS 816431-72-8) in rats is therefore above 2000 mg/kg body weight.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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