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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
bioaccumulation in aquatic species: fish
Type of information:
(Q)SAR
Remarks:
estimated by calculation
Adequacy of study:
supporting study
Study period:
2016
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: US EPA Method
Justification for type of information:
SOFTWARE:
US EPA. Estimation Programs Interface Suite (EpiSuite) v4.11

MODEL (incl. version number):
BCF/BAF v3.01

SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL:
COC(=O)CCCCCCCCCCCCCCCCC(=O)OC

ADEQUACY OF THE RESULT:
Results considered sufficient as supporting information in e-fate assessment.
Qualifier:
no guideline followed
Principles of method if other than guideline:
The EpiSuite v4.11 BCFBAF v3.01 program estimates BCF of an organic compound using the compound's log octanol-water partition coefficient (Kow). The estimation methodology used by the BCFWIN program was published by Meylan,WM, Howard,PH, Boethling,RS et al. 1999. Improved Method for Estimating Bioconcentration / Bioaccumulation Factor from Octanol/Water Partition Coefficient. Environ. Toxicol. Chem. 18(4): 664-672 (1999).
GLP compliance:
no
Remarks on result:
other: Based on the estimated upper trophic bioaccumulation factor (BAF) of 10 L/kg (EPISuite v4.11, BCFBAF v3.01), the bioaccumulation potential for the submitted substance is low

see attached report.

Conclusions:
Based on the estimated upper trophic bioaccumulation factor (BAF) of 10 L/kg (EPISuite v4.11, BCFBAF v3.01), the bioaccumulation potential for the submitted substance is low. In addition, the predicted BAF for middle and lower trophic levels were 42 and 338 L/kg, respectively. The downwards trend in BAF from lower to higher trophic levels is indicative of biodilution, the opposite of biomagnification.
Executive summary:

The upper trophic bioaccumulation factor (BAF) of octadecanedioic acid, 1,18-dimethyl ester (ODDAME) was estimated by EPISuite v4.11, BCFBAF v3.01 to be low (10 L/kg). In addition, the predicted BAF for middle and lower trophic levels were 42 and 338 L/kg, respectively. The downwards trend in BAF from lower to higher trophic levels is indicative of biodilution, the opposite of biomagnification.

Description of key information

The bioaccumulation potential of octadecanedioic acid, 1,18-dimethyl ester (ODDAME) is considered to be low.

Key value for chemical safety assessment

Additional information

The upper trophic bioaccumulation factor (BAF) of octadecanedioic acid, 1,18-dimethyl ester (ODDAME) was estimated by EPISuite v4.11, BCFBAF v3.01 to be low (10 L/kg). In addition, the predicted BAF for middle and lower trophic levels were 42 and 338 L/kg, respectively. The downwards trend in BAF from lower to higher trophic levels is indicative of biodilution, the opposite of biomagnification.