Registration Dossier
Registration Dossier
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EC number: 222-314-9 | CAS number: 3423-25-4
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19 April - 06 September 2001
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Endo-8-isopropyl-8-azabicyclo[3.2.1]octan-3-ol
- EC Number:
- 222-314-9
- EC Name:
- Endo-8-isopropyl-8-azabicyclo[3.2.1]octan-3-ol
- Cas Number:
- 3423-25-4
- Molecular formula:
- C10H19NO
- IUPAC Name:
- Endo-8-isopropyl-8-azabicyclo[3.2.1]octan-3-ol
- Test material form:
- solid: particulate/powder
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Species: Daphnia magna (Straus), clone 5
Age at Test Start: 6 - 21 hours old
Sex: female
Origin:
-supplier 1997 by the Umweltbundesamt, Institut für Wasser-Boden-und Lufthygiene, Berlin, Germany.
Breeding Conditions:
- The daphnia were bred in the laboratories of IBACON under similar temperature and light conditons as in the test, and in reconstituted water of a similar quality regarding tp pH, components of the main ions and total hardness as the test water used in the test. The test organisms were not first brood progency.
Toxic Standard:
- For the evaluation of the quality of the daphnia clone and the experimental conditions the substance potassium dichromate p.A. (E. Merck, Darmstadt, Germany) is tested at least twice a year to deminstrate satisfactory test conditions.
Acclimatisation:
for 6 hours under test conditions.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 48 h
Test conditions
- Nominal and measured concentrations:
- Nominal concentration: 100 mg/L
- Details on test conditions:
- -20 Daphnia per control and test concentration.
-Surrounding Type: controlled environment room
Water Temperature: 21 - 22°C
Light Regime: 16h light : 8h dark
Light Intensity: 470 lux
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 24 h
- Dose descriptor:
- EC0
- Effect conc.:
- >= 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 24 h
- Dose descriptor:
- EC100
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 21 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- 21 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
Applicant's summary and conclusion
- Conclusions:
- The 24-hour EC 50 and EC 100 of the test item were higher than 100 mg test item/L. The 24-hour EC 0 was at least 100 mg test item/L.
The 48-hour EC 50 and the EC 100 were higher than 100 mg test itemIL. The 48-hour EC 0 and the 48-hour NOEC (highest concentration tested
without toxic effects after 48 hours) of N-Isopropylnortropin were determined to be 21 mg test item/L, since no significant immobilization rate
and no other signs of intoxication were observed at the test animals up to and including this test concentration.
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