Registration Dossier
Registration Dossier
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EC number: 449-680-4 | CAS number: -
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 92/69/EWG, B.14 (Ames-Test)
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Method
Species / strain
- Species / strain / cell type:
- bacteria, other: sat TA 98, 100, 102, 1535, 1537
- Metabolic activation system:
- Mit Aroclor 1254 induzierter Rattenleber S9-Mix. "ENGLISH" Rat-liver S9 mix induced with Aroclor 1254.
- Test concentrations with justification for top dose:
- Concentration range in the main test (with metabolic activation): 16 ... 5000 µg/plate
Concentration range in the main test (without metabolic activation): 16 ... 5000 µg/plate - Vehicle / solvent:
- Solvent: DMSO
Results and discussion
Test resultsopen allclose all
- Species / strain:
- other: as specified above
- Metabolic activation:
- with
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- ( 500 µg/plate)
- Species / strain:
- other: as specified above
- Metabolic activation:
- without
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- ( 500 µg/plate)
- Additional information on results:
- Observations:
Der Stamm TA 1537 zeigte einen biologisch relevanten
Anstieg im Vergleich zur negativ-Kontrolle.
Der Anstieg wurde nur mit S9-Mix beobachtet.
"ENGLISH"
The species TA 1537 exhibited a biologically relevant
increase in comparison with the negative control.
The increase was only observed with the S9 mix. - Remarks on result:
- other: other: main test
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
positive with metabolic activation
negative without metabolic activation
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