Registration Dossier
Registration Dossier
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EC number: 483-350-0 | CAS number: -
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 05 Apr - 01 Jun 2006
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Version / remarks:
- 1992
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- 2004
- GLP compliance:
- yes (incl. QA statement)
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Test material form:
- liquid
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Daphnia magna
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- 271.32 mg/L CaCO3
- Nominal and measured concentrations:
- - Nominal concentrations: 0.1, 0.23, 0.51, 1.1, 2.5, 5.4, 11.9 mg/L
- Measured concentrations 0 h (new): 0.074, 0.188, 0.429, 0.939, 2.273, 4.7, 10.567
- Measured concenatration 24 h (new): 0.055, 0.155, 0.369, 0.817, 1.967, 4.114, -
- Measured concentration 24 h (old): < 0.056, 0.063, 0.141, 0.313, 0.742, 1.623, 2.946
-Measured concentration 48 h (old): < 0.056, 0.054, 0.111, 0.278, 0.771, 1.633, -
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 1.423 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% confidence limits: 0.788 - 6.852 mg/L
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 1.885 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% confidence limits: 1.136 - 3.238
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The effect concentration for the short-term toxicity to aquatic inverterbrates is EC50 (48 h) = 1.423 mg/L (geom. mean).
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