Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 484-420-3 | CAS number: -
Endpoint summary
Administrative data
Description of key information
The acute oral study was performed according to OECD Guideline 423 and GLP principles and the acute dermal study was performed according to OECD Guideline 402 and GLP principles.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Oral:
In an acute oral toxicity study, according to OECD, EC, EPA and JMAFF test guidelines, female rats were exposed via gavage to 2000 mg/kg bw of Radialube 7819. Animals were subjected to daily observations and weekly determination of body weight. Macroscopic examination was performed after terminal sacrifice. No mortality occurred. Hunched posture was noted in all animals on Day 1 only. Bodyweight gain was considered normal and no abnormalities at macroscopic examination were found. Therefore, the oral LD50 of Radialube 7819 in rats was establised to exceed 2000 mg/kg bw.
Dermal:
In an acute dermal study, performed according to OECD, EC, EPA and JMAFF test guidelines, rats were exposed by a single dermal application to 2000 mg/kg bw of Radialube 7819 for 24 hours. Animals were subjected to daily observations and weekly determination of body weight. Macroscopic examination was performed after terminal sacrifice. No mortality occurred. Flat posture and chromodacryorrhoea (snout) were noted among animals. They recovered from the symptoms between day 2 and 6. Scales were seen in the treated skin area of the animals during the observation period. Bodyweight gain was considered normal and no abnormalities at macroscopic examination were found. Therefore, the dermal LD50 of Radialube 7819 in rats was establised to exceed 2000 mg/kg bw.
Justification for classification or non-classification
Based on the available data, the substance does not have to be classified for acute toxicity according to Directive 67/548/EEC and the CLP Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
