Registration Dossier
Registration Dossier
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EC number: 484-420-3 | CAS number: -
Endpoint summary
Administrative data
Description of key information
The repeated oral dose toxicity study was performed according to OECD Guideline 407 and GLP principles.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
Additional information
In a 28 -day oral repeated dose toxicity study, performed according to OECD/EC/EPA test guidelines, rats in groups of 5/sexe/dose were exposed to 0, 150, 450 and 1000 mg/kg bw/day of Radialube 7819 via gavage. These doses were based on a 5 -day range finding study. The following parameters wee evaluated: mortality, clinical signs, fob, body weight, food consumpation, haematology, biochemical parameters, macroscopy, organ weights and microscopy. No toxicologically significant changes were noted in any of the parameters investigated in this study. Therefore, a NOAEL of >=1000 mg/kg bw/day was derived.
Justification for classification or non-classification
Based on the available data, the substance does not have to be classified for repeated dose toxicity according to Directive 67/548/EEC and the CLP Regulation (EC) No 1272/2008.
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