Magnesium potassium titanium oxide

Toxicity to reproduction

Administrative data

Endpoint:

two-generation reproductive toxicity

Type of information:

experimental study

Adequacy of study:

key study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2010

Report date:

2010

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 416 (Two-Generation Reproduction Toxicity Study)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

EPA OPPTS 870.3800 (Reproduction and Fertility Effects)

Deviations:

no

Test guideline 3

Qualifier:

according to guideline

Guideline:

EU Method B.35 (Two-Generation Reproduction Toxicity Test)

Deviations:

no

Limit test:

no

Test material

Test material information

Constituent 1

Test animals

Species:

rat

Strain:

other:

Sex:

male/female

Administration / exposure

Route of administration:

oral: feed

Results and discussion

Results: P0 (first parental generation)

Effect levels (P0)

1

Dose descriptor:

NOAEL

Effect level:

>= 15 000 ppm (nominal)

Based on:

test mat.

Sex:

male/female

Basis for effect level:

other:

2

Dose descriptor:

other:

Effect level:

>= 15 000 ppm (nominal)

Based on:

test mat.

Sex:

male/female

Basis for effect level:

other:

Remarks on result:

other:

Results: F1 generation

Effect levels (F1)

Dose descriptor:

NOAEL

Generation:

F1

Effect level:

>= 15 000 ppm (nominal)

Based on:

test mat.

Sex:

male/female

Basis for effect level:

other:

Results: F2 generation

Effect levels (F2)

Dose descriptor:

NOAEL

Generation:

F2

Effect level:

>= 15 000 ppm (nominal)

Based on:

test mat.

Sex:

male/female

Basis for effect level:

other:

Overall reproductive toxicity

Reproductive effects observed:

not specified