Registration Dossier
Registration Dossier
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EC number: 464-520-3 | CAS number: 189813-45-4
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- GLP compliance:
- yes
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- - Name of test material (as cited in study report): 520 F - Chlormethyloximether
- Analytical purity: 94.4 g/100 g
- Batch No.: 31196-182
- Storage condition of test material: ambient temperature
Study design
- Analytical monitoring:
- no
- Buffers:
- - Buffer pH 4.0 (citric acid, sodium chloride, sodium hydroxide)
- Buffer pH 7.0 (phosphate mixture)
- Buffer pH 9.0 (sodium borate, hydrochloric acid; acetonitrile) - Details on test conditions:
- PROCEDURE
About 17 - 18 mg of the test item exactly weighed were dissolved in 100 ml of buffer pH 4, 7 or 9 respectively. In cases where obviously undissolved amounts of test item caused problems, the solutions were filtrated. The solutions were heated at 50.0°C ± 0.1 °C (or 40.0°C ± 0.1 °C, respectively) and injected after defined time intervals into the HPLC system
Results and discussion
Dissipation DT50 of parent compoundopen allclose all
- pH:
- 4
- Temp.:
- 50 °C
- Hydrolysis rate constant:
- 0.042 h-1
- DT50:
- 16.4 h
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 4
- Temp.:
- 40 °C
- Hydrolysis rate constant:
- 0.014 h-1
- DT50:
- 49.6 h
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 7
- Temp.:
- 50 °C
- Hydrolysis rate constant:
- 0.063 h-1
- DT50:
- 11.1 h
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 7
- Temp.:
- 40 °C
- Hydrolysis rate constant:
- 0.023 h-1
- DT50:
- 30.7 h
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 9
- Temp.:
- 50 °C
- DT50:
- <= 2.4 h
- Type:
- (pseudo-)first order (= half-life)
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
