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Toxicological information

Sensitisation data (human)

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Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable publication which meets basic scientific principles

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
4-Aminoazobenzene. BUA-Stoffbericht 217
Author:
Beratergremium für Altstoffe (BUA)
Year:
1998
Bibliographic source:
BUA der Gesellschaft dt. Chemiker, S. Hirzel Wissenschaftliche Verlagsgesellschaft, Stuttgart
Reference Type:
publication
Title:
Sensitization induced by patch testing
Author:
Agrup G
Year:
1968
Bibliographic source:
Br J Dermatol. 80: pp:631-634
Reference Type:
publication
Title:
Dermatitis from an azo-dye in industrial Ieather protective shoes
Author:
Ancona A, Serviere L, Trejo A, Monroy F
Year:
1982
Bibliographic source:
Contact Dermatitis 8: pp. 220-221
Reference Type:
publication
Title:
Contact dermatitis from a stamp-ink of the German post ofiice
Author:
Braun WPH
Year:
1975
Bibliographic source:
Contact Dermatitis 1, 189
Reference Type:
publication
Title:
Cosmetic intolerance
Author:
Broeckx W, et al.
Year:
1987
Bibliographic source:
Contact Dermatitis 16: 189-194
Reference Type:
publication
Title:
Contact dermatitis of the feet
Author:
Correia S, Brandao FM
Year:
1986
Bibliographic source:
Dermatosen Beruf Umwelt 34: 102-105
Reference Type:
publication
Title:
Textile dye dermatitis
Author:
Dooms-Goossens A
Year:
1992
Bibliographic source:
Contact Dermatitis 27: 321-323
Reference Type:
publication
Title:
Investigations of group allergies to aromatic aminocompounds [Untersuchungen zur Gruppenallergie bei aromatischen Amino- Verbindungen]
Author:
Düngernann H, Borelli S
Year:
1966
Bibliographic source:
Berufs-Dermatosen 14,281-295
Reference Type:
publication
Title:
Patch test results with a shoewear screening tray in 119 patients, 1977-1980
Author:
Lynde CW, Warshawski L, Mitchell JC
Year:
1982
Bibliographic source:
Contact Dermatitis 8: 423-425
Reference Type:
publication
Title:
Standard patch tests in agncultural workers.
Author:
Garcia-Perez A, et al.
Year:
1984
Bibliographic source:
Contact Dermatitis 10: 151-153

Materials and methods

Type of sensitisation studied:
skin
Study type:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Any other information on results incl. tables

Numerous patient cohorts and occupationally exposed persons clearly reacted positively to 4-Aminoazobenzene in concentrations of 0.25 - 2 % in vaseline or methylethylketone in the epicutaneous test. Moreover, several case descriptions exist in which positive reactions by 4-Aminoazobenzene in concentrations of 0.25 - 5 % could be triggered in individuals with dermatitis.

(IUCLID, 1996: Arnold et al., 1995; Bruynzeel et al., 1983; Degreef et al., 1985; Dooms-Goossens et al., 1987; Foussereau et al., 1986; Goh and Kozuka, 1986; Hausen, 1994; Hjorth and Rothenborg, 1967; Katoh et al., 1986; Manzini et al., 1991; Matsunaga et al., 1990; Prens et al., 1986; Roeleveld and van Ketel, 1975, 1976; Saha et al., 1993; Schubert et al., 1987; Schulz, 1962; Seidenari et al., 1997; Thierbach et al., 1992; Thune, 1984; Uter et al., 1993, 1996).

Applicant's summary and conclusion