Registration Dossier
Registration Dossier
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EC number: 202-863-0 | CAS number: 100-54-9
Biodegradation in water and sediment: simulation tests
Administrative data
- Endpoint:
- biodegradation in water and sediment: simulation tests
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given, comparable to guidelines/standards.
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicity and Anaerobic Biodegradability of Pyridine and Its Derivatives Under Sulfidogenic Conditions.
- Author:
- Lui SM, Wu CH and Huang HJ
- Year:
- 1 989
- Bibliographic source:
- Chemosphere 10: 2345-2357
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Assessment of degradation based on substrate depletion in sediment slurries.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Nicotinonitrile
- EC Number:
- 202-863-0
- EC Name:
- Nicotinonitrile
- Cas Number:
- 100-54-9
- Molecular formula:
- C6H4N2
- IUPAC Name:
- pyridine-3-carbonitrile
- Reference substance name:
- 3-Cyanolpyridine
- IUPAC Name:
- 3-Cyanolpyridine
- Details on test material:
- Purchased from Tokyo Kasei (Tokyo, Japan). No further details
Constituent 1
Constituent 2
Study design
- Oxygen conditions:
- anaerobic
- Remarks:
- sulfate-reducing conditions
- Inoculum or test system:
- other: estuarine sediment and overlying site water
- Details on source and properties of sediment:
- The sediment (<1mm, sieved) and overlying water (pH 7.48, salinity 13%, sulfate concentration 13.5 mM) water were collected from the estuary of Tansui River (Guandu, Taipei).
- Details on inoculum:
- The sediment (<1mm, sieved) and overlying water (pH 7.48, salinity 13%, sulfate concentration 13.5 mM) water were collected from the estuary of Tansui River (Guandu, Taipei).
- Duration of test (contact time):
- 200 d
Results and discussion
Half-life of parent compound / 50% disappearance time (DT50)
- Compartment:
- sediment
- DT50:
- 1 d
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: Half-life is less than 1 day
- Other kinetic parameters:
- pseudo-first order rate constant
Any other information on results incl. tables
3 -Cyanopyridine was transformed into an intermediate product in 19 days, with a lag time of 4 days.
Applicant's summary and conclusion
Validity criteria
- Validity criteria fulfilled:
- not applicable
- Remarks:
- not a guideline study
- Conclusions:
- 3-Cyanopyridine showed evidence of anaerobic degradation in sediment slurries, with a half-life of less than 1 day, and dull degradation within 19 days.
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