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Administrative data

Description of key information

Ammonium zinc chloride dissioziates with humidity to ammonium chloride and zinc chloride,
Zinc chloride is corrosive based on animal skin irritation studies. Due the corrosive nature of zinc chloride to skin, eye irritation studies do not need to be conducted and hence no animal eye irritation data is available on zinc chloride.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

Test substance

 Study type

 Species

 Endpoint

 Exposure

 Result

Remarks

 Reference

Zinc chloride

Skin irritation

Guinea-pig

Erythema, eschar and oedema formation

Daily; 0.5 mL of 1% solution; open-patch; 5 days

Moderately irritating

2 (reliable with restrictions)

key study

LansdownABG,(1991)

Zinc chloride

Skin irritation

Rabbit

Erythema, eschar and oedema formation

Daily; 0.5 mL of 1% solution; open-patch; 5 days

Severely irritating

2 (reliable with restrictions)

key study

LansdownABG,(1991)

Zinc chloride

Skin irritation

Rabbit

Erythema, eschar and oedema formation

Daily; 0.5 mL of 1% solution; occluded; 5 days

Severely irritating

2 (reliable with restrictions)

key study

LansdownABG,(1991)

Zinc chloride

Skin irritation

Mouse

Erythema, eschar and oedema formation

Daily; 0.5 mL of 1% solution; open-patch; 5 days

Severely irritating

2 (reliable with restrictions)

key study

LansdownABG,(1991)

Zinc sulphate

Skin irritation

Rabbit

Erythema, eschar and oedema formation

0.5g; moistened substance; semi-occlusive; 4 hours

Not irritating

2 (reliable with restrictions)

key study

 

Van Huygevoort AHBM (1999b)

Zinc sulphate

Skin irritation

Rabbit

Erythema, eschar and oedema formation

Daily; 0.5 mL; open-patch; 5 days

Not irritating

2 (reliable with restrictions)

key study

 

LansdownABG,(1991)

Zinc sulphate

Skin irritation

Guinea Pig

Erythema, eschar and oedema formation

Daily; 0.5 mL; open-patch; 5 days

Not irritating

2 (reliable with restrictions)

key study

LansdownABG,(1991)

Zinc sulphate

Skin irritation

Mouse

Erythema, eschar and oedema formation

Daily; 0.5 mL; open-patch; 5 days

Not irritating

2 (reliable with restrictions)

key study

LansdownABG,(1991)

Zinc oxide

Skin irritation

Rabbit

Erythema, eschar and oedema formation

500 mg; occlusive; 24 hours

Not irritating

2 (reliable with restrictions)

key study

 

Löser, (1977)

Zinc oxide

Skin irritation

Rabbit

Erythema, eschar and oedema formation

Daily; 0.5 mL; occlusive; 5 days

Not irritating

2 (reliable with restrictions)

key study

 

LansdownABG,(1991)

Zinc oxide

Skin irritation

Rabbit

Erythema, eschar and oedema formation

Daily; 0.5 mL; open patch; 5 days

Not irritating

2 (reliable with restrictions)

key study

 

LansdownABG,(1991)

Zinc oxide

Skin irritation

Guinea-pig

Erythema, eschar and oedema formation

Daily; 0.5 mL; open

Not irritating

2 (reliable with restrictions)

key study

 

LansdownABG,(1991)

Zinc oxide

Skin irritation

Mouse

Erythema, eschar and oedema formation

Daily; 0.5 mL; open

Not irritating

2 (reliable with restrictions)

key study

 

LansdownABG,(1991)



Effects on skin irritation/corrosion: highly irritating

Effects on eye irritation: highly irritating

Effects on respiratory irritation: irritating

Justification for classification or non-classification

Based on the available data of the soluble zinc compounds, soluble zinc chloride is classified as corrosive (C;R34) according to EC criteria due to severe skin irritancy seen in animals at concentrations of 1% solution and irreversible damage to eyes caused by zinc chloride after accidental exposure in humans. Zinc chloride has also shown signs of respiratory tract irritation in single exposure studies (see acute inhalation toxicity).