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EC number: 219-741-8 | CAS number: 2517-43-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant, guideline study, available as unpublished report. No restrictions, fully adequate for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 3-methoxybutan-1-ol
- EC Number:
- 219-741-8
- EC Name:
- 3-methoxybutan-1-ol
- Cas Number:
- 2517-43-3
- Molecular formula:
- C5H12O2
- IUPAC Name:
- 3-methoxybutan-1-ol
- Reference substance name:
- methoxybutanol
- IUPAC Name:
- methoxybutanol
- Details on test material:
- - Name of test material (as cited in study report): methoxybutanol
- Physical state: clear, colourless liquid
- Analytical purity: 99.5%
- Lot/batch No.: Hoe CG 0388 0A ZD00 0001
- Expiration date of the lot/batch: August 1996
- pH in water: 7
- Storage condition of test material: in the dark at room temperature
- Stability under test conditions: 4 hours in vehicle
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hoechst AG, Kastengrund, SPF Zucht
- Age at study initiation: 7-8 weeks
- Weight at study initiation: 193±8 g (males); 182±3 g (females)
- Fasting period before study: 16 hrs
- Housing: 5 per cage
- Diet: Rattendiat Altromin 1324 ad libitum
- Water: Tap water in bottles ad libitum
- Acclimation period: not required. (Identical to the pre-study conditions)
ENVIRONMENTAL CONDITIONS
- Temperature: 22±3°C
- Humidity: 55±20%
- Air changes (per hr): no data
- Photoperiod: 12 hrs dark / 12 hrs light
IN-LIFE DATES: From: 16 October to 5 November 1991
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 20% (w/v)
- Amount of vehicle (if gavage): 10 mL/kg - Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Frequently observed on the day of dosing and then at least daily; weighed on days 0, 7 and 14.
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- One female died on the day after dosing.
- Clinical signs:
- other: other: Clinical signs seen in most animals included irregular respiration, stupor, coat bristling, flanks drawn in, stilted or uncoordinated gait, ataxia and decreased activity.
- Gross pathology:
- The female that was found dead had light discolouration of the liver and the small intestine contained a reddish-black, haemoccult positive, mass. No abnormalities were seen in the animals that survived to study termination.
Any other information on results incl. tables
All animals appeared normal by day 3.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral LD50 of methoxybutanol was >2000 mg/kg to male and female rats.
- Executive summary:
In an acute oral study with male and female Wistar rats, methoxybutanol was dosed orally, by gavage, at 2000 mg/kg in water. Animals were observed daily for a further 14 days and weighed at weekly intervals. On day 15, rats were killed and examined grossly. One female died on the day after dosing.Clinical signs seen in most animals on day 1, included irregular respiration, stupor, coat bristling, flanks drawn in, stilted or uncoordinated gait, ataxia and decreased activity.
All animals appeared normal by day 3 and gained weight during the study. Discolouration of the liver and a reddish-black mass in the small intestine were present in the female that died. No gross abnormalities were seen in the animals that survived to study termination.
The LD50 of methoxybutanol was >2000 mg/kg.
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