Registration Dossier
Registration Dossier
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EC number: 219-741-8 | CAS number: 2517-43-3
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only short summary of proprietary study available, contributing to weight of evidence.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 930
Materials and methods
- Principles of method if other than guideline:
- Various species were exposed for 1 or 6 hours to air saturated with test substance i.e. ca. 6,200 mg/m3.
- GLP compliance:
- no
- Test type:
- other:
- Limit test:
- no
Test material
- Reference substance name:
- 3-methoxybutanol
- IUPAC Name:
- 3-methoxybutanol
- Reference substance name:
- 3-methoxybutan-1-ol
- EC Number:
- 219-741-8
- EC Name:
- 3-methoxybutan-1-ol
- Cas Number:
- 2517-43-3
- Molecular formula:
- C5H12O2
- IUPAC Name:
- 3-methoxybutan-1-ol
Constituent 1
Constituent 2
Test animals
- Species:
- other: cats, rabbits and guinea pigs
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- air
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- ca. 1 - ca. 6 h
- Concentrations:
- Saturated air, i.e. ca. 6.2 mg/L (6,200 mg/m3)
- No. of animals per sex per dose:
- No data
- Control animals:
- not specified
Results and discussion
Effect levelsopen allclose all
- Dose descriptor:
- other: notable symptoms
- Exp. duration:
- 6 h
- Remarks on result:
- other: Cats: 1 cat with signs of mild irritation/drowsiness, but later lively without symptoms.
- Dose descriptor:
- other: notable symptoms
- Exp. duration:
- 6 h
- Remarks on result:
- other: Rabbits and guinea pigs - no symptoms
- Mortality:
- No mortality
- Clinical signs:
- other: Cats: - After 1 hour exposure - mild irritation of the accessible mucous membranes (flow of saliva and tears). Following 6 hours of exposure 1 cat showed signs of mild irritation/drowsiness but was later lively and symptom free. Otherwise no notable symp
Applicant's summary and conclusion
- Conclusions:
- Exposure to saturated vapours of 3-methoxybutanol (6200 mg/m3) only caused slight irritation of the accessible mucous membranes after 1 and 6 hour exposures in cats. 1 cat was slightly drowsy for a time in the 6 hour exposure but was later lively. Rabbits and guinea pigs showed no adverse clinical effects.
- Executive summary:
In an acute inhalation study, cats, rabbits and guinea pigs were exposed to saturated vapours of butoxyl for 1 and 6 hours. Only slight irritation of the accessible membranes was seen in cats after 1 or 6 hour exposures. 1 cat was reported to appear drowsy for a time. There were no effects of treatment for rabbits and guinea pigs.
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