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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only short summary of proprietary study available, contributing to weight of evidence.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1930

Materials and methods

Principles of method if other than guideline:
Various species were exposed for 1 or 6 hours to air saturated with test substance i.e. ca. 6,200 mg/m3.
GLP compliance:
no
Test type:
other:
Limit test:
no

Test material

Constituent 1
Reference substance name:
3-methoxybutanol
IUPAC Name:
3-methoxybutanol
Constituent 2
Chemical structure
Reference substance name:
3-methoxybutan-1-ol
EC Number:
219-741-8
EC Name:
3-methoxybutan-1-ol
Cas Number:
2517-43-3
Molecular formula:
C5H12O2
IUPAC Name:
3-methoxybutan-1-ol

Test animals

Species:
other: cats, rabbits and guinea pigs
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
air
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
ca. 1 - ca. 6 h
Concentrations:
Saturated air, i.e. ca. 6.2 mg/L (6,200 mg/m3)
No. of animals per sex per dose:
No data
Control animals:
not specified

Results and discussion

Effect levelsopen allclose all
Dose descriptor:
other: notable symptoms
Exp. duration:
6 h
Remarks on result:
other: Cats: 1 cat with signs of mild irritation/drowsiness, but later lively without symptoms.
Dose descriptor:
other: notable symptoms
Exp. duration:
6 h
Remarks on result:
other: Rabbits and guinea pigs - no symptoms
Mortality:
No mortality
Clinical signs:
other: Cats: - After 1 hour exposure - mild irritation of the accessible mucous membranes (flow of saliva and tears). Following 6 hours of exposure 1 cat showed signs of mild irritation/drowsiness but was later lively and symptom free. Otherwise no notable symp

Applicant's summary and conclusion

Conclusions:
Exposure to saturated vapours of 3-methoxybutanol (6200 mg/m3) only caused slight irritation of the accessible mucous membranes after 1 and 6 hour exposures in cats. 1 cat was slightly drowsy for a time in the 6 hour exposure but was later lively. Rabbits and guinea pigs showed no adverse clinical effects.
Executive summary:

In an acute inhalation study, cats, rabbits and guinea pigs were exposed to saturated vapours of butoxyl for 1 and 6 hours. Only slight irritation of the accessible membranes was seen in cats after 1 or 6 hour exposures. 1 cat was reported to appear drowsy for a time. There were no effects of treatment for rabbits and guinea pigs.