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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only short summary of proprietary study available, contributing to weight of evidence.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1930

Materials and methods

Principles of method if other than guideline:
Various species were exposed for 1 or 6 hours to air saturated with test substance i.e. ca. 10,000 mg/m3.
GLP compliance:
no
Test type:
other:
Limit test:
no

Test material

Constituent 1
Reference substance name:
butoxyl
IUPAC Name:
butoxyl
Constituent 2
Chemical structure
Reference substance name:
3-methoxybutyl acetate
EC Number:
224-644-9
EC Name:
3-methoxybutyl acetate
Cas Number:
4435-53-4
Molecular formula:
C7H14O3
IUPAC Name:
3-methoxybutyl acetate
Details on test material:
No data

Test animals

Species:
other: cats, rabbits and guinea pigs
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
air
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
ca. 1 - ca. 6 h
Concentrations:
Saturated air, i.e. ca. 10 mg/L (10,000 mg/m3)
No. of animals per sex per dose:
No data
Control animals:
not specified

Results and discussion

Effect levelsopen allclose all
Dose descriptor:
other: notable symptoms
Exp. duration:
1 h
Remarks on result:
other: Cats: mild irritation of the accessible mucous membranes (flow of saliva and tears). Otherwise no notable symptoms.
Dose descriptor:
other: notable symptoms
Exp. duration:
6 h
Remarks on result:
other: Cats: signs of mild irritation to the mucous membranes (eyes). Otherwise no notable symptoms.
Dose descriptor:
other: notable symptoms
Exp. duration:
1 h
Remarks on result:
other: Rabbits - no symptoms
Dose descriptor:
other: notable symptoms
Exp. duration:
6 h
Remarks on result:
other: Rabbits - signs of mild irritation to the mucous membranes (eyes). Otherwise no notable symptoms.
Mortality:
No mortality
Clinical signs:
other: Cats: - After 1 hour exposure - mild irritation of the accessible mucous membranes (flow of saliva and tears). Following 6 hours of exposure cats showed signs of mild irritation to the mucous membranes. Otherwise no notable symptoms. Rabbits: - No sympto

Applicant's summary and conclusion

Conclusions:
Exposure to saturated vapours of butoxyl (10000 mg/m3) only caused slight irritation of the accessible mucous membranes after 1 and 6 hour exposures in cats and rabbits.
Executive summary:

In an acute inhalation study, cats, rabbits and guinea pigs were exposed to saturated vapours of butoxyl for 1 and 6 hours. Only slight irritation of the accessible membranes was seen in cats and rabbits after 1 and 6 hour exposures. Butoxyl was considered to be of low acute inhalation toxicity.