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EC number: 224-644-9 | CAS number: 4435-53-4
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only short summary of proprietary study available, contributing to weight of evidence.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 930
Materials and methods
- Principles of method if other than guideline:
- A 10% solution of 3-methoxybutyl acetate in oil was injected subcutaneously to 1 guinea pig at a single dose of 0.1 g/kg and to another guinea pig, at the same dose, on 6 consecutive days (see 7.5.4). Rats were also dosed subcutaneously with a 10% solution of 3-methoxybutyl acetate in oil at a single dose of 0.5 g/kg and 1 g/kg.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 3-methoxybutyl acetate
- EC Number:
- 224-644-9
- EC Name:
- 3-methoxybutyl acetate
- Cas Number:
- 4435-53-4
- Molecular formula:
- C7H14O3
- IUPAC Name:
- 3-methoxybutyl acetate
- Reference substance name:
- butoxyl
- IUPAC Name:
- butoxyl
- Details on test material:
- Name of test material (as cited in study report): 3-methoxy-1-butyl acetate
Constituent 1
Constituent 2
Test animals
- Species:
- other: guinea pig and rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data.
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- other: oil
- Details on exposure:
- A 10% solution of 3-methoxybutyl acetate in oil was injected subcutaneously, as a single dose, to 1 guinea pig and to rats. No further details provided.
- Doses:
- 0.1 g/kg - guinea pig; 0.5 or 1.0 g/kg - rats
- No. of animals per sex per dose:
- 1 (rats not specified)
- Control animals:
- no
- Details on study design:
- no data
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- other: No effect level
- Effect level:
- 1 000 mg/kg bw
- Remarks on result:
- other: a single dose of 0.5 g/kg and 1 g/kg did not cause any symptoms in rats
- Clinical signs:
- No adverse clinical signs were seen.
Applicant's summary and conclusion
- Conclusions:
- A single subcutaneous injection of a 10% solution of 3-methoxybutyl acetatel in oil did not cause any adverse effects to a guinea pig (at a dose of 100 mg/kg) or to rats at a dose of 500 or 1000 mg/kg.
- Executive summary:
A 10% solution of 3 -methoxybutyl acetate in oil was injected subcutaneously to a guinea pig at a dose of 100 mg/kg and to rats at a dose of 500 or 1000 mg/kg on a single occasion. There were no adverse clinical signs. 3 -Methoxybutyl acetate, as a 10% solution in oil, was of low toxicity to by the subcutaneous route to guinea pigs at a dose level of 100 mg/kg/day and to rats at 500 or 1000 mg/kg.
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