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Administrative data

Endpoint:
short-term repeated dose toxicity: other route
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only short summary of proprietary study available, contributing to weight of evidence.
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1930

Materials and methods

Principles of method if other than guideline:
A guinea pigs was injected subcutaneously with a 10% solution of 3-methoxybutyl acetate in oil for up to 6 days. Single doses were also given to another guinea pig and to rats (see 7.5.2).
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3-methoxybutyl acetate
EC Number:
224-644-9
EC Name:
3-methoxybutyl acetate
Cas Number:
4435-53-4
Molecular formula:
C7H14O3
IUPAC Name:
3-methoxybutyl acetate
Constituent 2
Reference substance name:
4435-43-3
IUPAC Name:
4435-43-3
Constituent 3
Reference substance name:
butoxyl
IUPAC Name:
butoxyl
Details on test material:
No data

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No details given

Administration / exposure

Route of administration:
subcutaneous
Vehicle:
other: oil
Details on exposure:
A 10% solution of 3-methoxybutyl acetate in oil was injected subcutaneously to 1 guinea pig, at a dose of 0.1 g/kg, on 6 consecutive days.
Analytical verification of doses or concentrations:
no
Duration of treatment / exposure:
6 days
Frequency of treatment:
Daily
Doses / concentrations
Remarks:
Doses / Concentrations:
0.1 g/kg
No. of animals per sex per dose:
1
Control animals:
no
Details on study design:
No data

Results and discussion

Results of examinations

Clinical signs:
no effects observed
Mortality:
no mortality observed
Body weight and weight changes:
not specified
Food consumption and compound intake (if feeding study):
not specified
Food efficiency:
not specified
Water consumption and compound intake (if drinking water study):
not specified
Ophthalmological findings:
not specified
Haematological findings:
not specified
Clinical biochemistry findings:
not specified
Urinalysis findings:
no effects observed
Behaviour (functional findings):
not specified
Organ weight findings including organ / body weight ratios:
not specified
Gross pathological findings:
not specified
Histopathological findings: non-neoplastic:
not specified
Histopathological findings: neoplastic:
not specified
Details on results:
There were no adverse symptoms and no abnormalities were found in the urine. No other details provided in translation document.

Effect levels

Dose descriptor:
NOAEL
Effect level:
100 mg/kg bw/day
Sex:
not specified
Basis for effect level:
other: No adverse clinical signs were seen in guinea pigs after 6 daily injections of 0.1 g/kg.

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
Subcutaneous injection of a 10% solution of 3-methoxybutyl acetate in oil did not cause any adverse effects to guinea pigs at a dose of 100 mg/kg/day for up to 6 days.
Executive summary:

A 10% solution of 3 -methoxybutyl acetate in oil was injected subcutaneously to a guinea pig at a dose of 100 mg/kg for 6 consecutive days. There were no adverse clinical signs and no abnormal findings in the urine. 3 -Methoxybutyl acetate, as a 10% solution in oil, was of low toxicity to guinea pigs by the subcutaneous route at a dose level of 100 mg/kg/day.