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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1991
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: citation form second source
Justification for type of information:
substance is with 30% part of the reaction mass

Data source

Reference
Reference Type:
other: MSCA statement
Title:
Unnamed
Year:
2010
Report date:
2010

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Deviations:
not specified
GLP compliance:
not specified
Test type:
other:
Limit test:
yes

Test material

Constituent 1
Reference substance name:
Tetraethyl orthosilicate
EC Number:
201-083-8
EC Name:
Tetraethyl orthosilicate
Cas Number:
78-10-4
IUPAC Name:
tetraethyl orthosilicate
Details on test material:
Ethysilikat TEOS 40, purity: 99.78, form Hoechst AG

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
4 h
Concentrations:
no data
No. of animals per sex per dose:
10 per concentration, number of tested concentrations unknown
Control animals:
not specified

Results and discussion

Effect levelsopen allclose all
Key result
Sex:
female
Dose descriptor:
LC50
Effect level:
> 1 950 ppm
Based on:
test mat.
Exp. duration:
4 h
Remarks on result:
other: MMAD = 0.8µm
Key result
Sex:
male
Dose descriptor:
LC50
Effect level:
1 160 ppm
Based on:
test mat.
Exp. duration:
4 h
Remarks on result:
other: MMAD = 0.8 µm

Any other information on results incl. tables

Mean value: 1555 ppm

Conversion factor: 8.66 mg/m³ = 1 ppm (Source: SCOEL/SUM/64 form June 2007)

=> LC50(rat, 4h)=13.5 mg/L

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category IV
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The mean value acute inhalation toxicity in rats was determined to be 13.5 mg/L