Registration Dossier
Registration Dossier
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EC number: 300-344-4 | CAS number: 93925-42-9
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1991
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: citation form second source
- Justification for type of information:
- substance is with 30% part of the reaction mass
Data source
Reference
- Reference Type:
- other: MSCA statement
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test type:
- other:
- Limit test:
- yes
Test material
- Reference substance name:
- Tetraethyl orthosilicate
- EC Number:
- 201-083-8
- EC Name:
- Tetraethyl orthosilicate
- Cas Number:
- 78-10-4
- IUPAC Name:
- tetraethyl orthosilicate
- Details on test material:
- Ethysilikat TEOS 40, purity: 99.78, form Hoechst AG
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- Concentrations:
- no data
- No. of animals per sex per dose:
- 10 per concentration, number of tested concentrations unknown
- Control animals:
- not specified
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- female
- Dose descriptor:
- LC50
- Effect level:
- > 1 950 ppm
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: MMAD = 0.8µm
- Key result
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 1 160 ppm
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: MMAD = 0.8 µm
Any other information on results incl. tables
Mean value: 1555 ppm
Conversion factor: 8.66 mg/m³ = 1 ppm (Source: SCOEL/SUM/64 form June 2007)
=> LC50(rat, 4h)=13.5 mg/L
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The mean value acute inhalation toxicity in rats was determined to be 13.5 mg/L
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