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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: acceptable publication which meets basic scientic principles; basic data on expermimental design are given.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Range-Finding Toxicity Data: List VII
Author:
Smyth, HF; Carpenter, CP; Weil, CS; Pozzani UC; Striegel JA; Nycum, JS
Year:
1969
Bibliographic source:
Amer. Ind. Hyg. Assoc. J. 30 (1969), 470
Report date:
1969
Reference Type:
publication
Title:
Range-Finding Toxicity Data: List VI
Author:
Smyth, HF; Carpenter, CP; Weil, CS; Pozzani UC; Striegel JA
Year:
1962
Bibliographic source:
Amer. Ind. Hyg. Assoc. J. 23 (1962), 95
Report date:
1962

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
primary skin irritation test. 0,01 ml of undiluted sample or solutions in water, acetone or propylene glycol are applied to clipped skin of 5 albino rabbits. After 24h the reaction is graded on a scale from 1 to 10.
GLP compliance:
no
Remarks:
pre-GLP

Test material

Constituent 1
Chemical structure
Reference substance name:
8,9,10-trinorborn-2-ene
EC Number:
207-866-0
EC Name:
8,9,10-trinorborn-2-ene
Cas Number:
498-66-8
Molecular formula:
C7H10
IUPAC Name:
Bicyclo-[2.2.1]-hept-2-ene
Details on test material:
no further details given

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals or test system and environmental conditions:
no data

Test system

Type of coverage:
open
Preparation of test site:
other: clipped
Vehicle:
other: either acetone or propylene glycol
Controls:
not specified
Amount / concentration applied:
0,01 ml
Duration of treatment / exposure:
24h
Observation period:
24h
Number of animals:
5
Details on study design:
TEST SITE
- Area of exposure: rabbit belly
- % coverage: no data
- Type of wrap if used: application site uncovered

REMOVAL OF TEST SUBSTANCE
- Washing (if done): no data
- Time after start of exposure: no data

SCORING SYSTEM: scoring in grading system from 1 to 10. 1 indicates no irritiation, 2 the least visible capillary injection from the undilted chemical. Grade 6 indicates necrosis, when undiluted and grade10 indicates necrosis from a 0,01% solution.

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
other: no data
Time point:
other: 24 h
Score:
1
Max. score:
10
Reversibility:
other: not applicable
Remarks on result:
other: own grading system, 1= no effect

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Executive summary:

the primary skin irritation of a 0,01% solution of the test substance on the clipped belly of albino rabbits on a 24h exposure period was tested on each of 5 rabbits. The result score of 1 out of a scale of 10 corresponds to no irritation having been observed under test conditions.