Registration Dossier

Administrative data

Description of key information

Skin irritation (EEC-Directive 92/69 B.4, according to GLP principles):

Monosodium L-glutamate has been tested in three New Zealand White rabbits for 4 hours in a semiocclusive setting. The skin irritating study elicited

transient very slight dermal reactions. The reactions were of a barely perceptible nature and were seen on one occasion in one animal only.

This isolated finding is not regarded as significant. It was concluded that the test substance is not irritating to the skin.

Eye irritation (EEC-Directive 92/69 B.5, according to GLP principles):

Monosodium L-glutamate has been tested in three New Zealand White rabbits for 24 hours. The eye irritating study elicited transient well-defined

conjunctival irritation. All reactions had resolved two days after instillation. It was concluded that the test substance is not irritating to the eye.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information

It can be concluded that monosodium glutamate is not considered irritating to skin and eye.

Justification for classification or non-classification

Based on the information in the discussion mentioned above, the substance is not classified as skin/eye irritant according to DSD and CLP.