Trifluoroacetic acid

Short-term toxicity to fish

Description of key information

A key study performed under OECD guideline 203 with GLP shows no toxicity on Danio rerio and gives an LC50 (96h) > 999 mg/L and a NOEC (96h) of 999 mg/L Trifluoroacetic acid. A supporting study performed under an ISO guideline gives a NOEC (96h) > 8000 mg/L on the same species.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Dose descriptor:

LC50

Effect concentration:

> 999 mg/L

Additional information

The key study for short term toxicity to fish was performed with Trifluoroacetate sodium on the freshwater fish, Danio rerio under static conditions for 96h according to OECD Guideline 203 and GLP (Groeneveld, 1992). All validity criteria were fulfilled, this study was reliable without restriction. The study is a limit test at 1200 mg/l of Trifluoroacetate sodium in duplicates (i.e. 999 mg/l of Trifluoroacetic acid, TFA) with control. No mortality was observed so the LC50 (96h) was determined as greater than 999 mg/l and the NOEC is equal to 999 mg/l of TFA.

An other 96h-acute toxicity study was performed, according to NF ISO 7346 -1, with Trifluoroacetic acid on the same species under static conditions (Barthel, 2008). A limit test was realized at 8000 mg/L of TFA with control. No mortality was observed after 96 hours therefore a NOEC (96h) greater than 8000 mg/L was derived. However, some critical information on the substance purity, the test conditions and results is missing in the report to consider this study as reliable. Therefore these results are used as supportive information.

The key value used for chemical safety assessment is an LC50 greater than 999 mg/L of Trifluoroacetic acid for short term toxicity on freshwater fish.