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EC number: 265-232-9 | CAS number: 64771-71-7 A combination of normal paraffins having carbon numbers predominantly greater than C10 obtained by urea adduction or molecular sieve processes.
Sensitivity analysis for selected decane model parameters at 200 ppm evaluated during exposure (3 h) and postexposure (5-25 h)
Decane is one of the highest vapor phase constituents of jet propellent-8 (JP-8), was selected to represent the semi-volatile fraction for the initial development of a physiologically based pharmacokinetic (PBPK) model for JP-8. Rats were exposed to decane vapors at time-weighted average concentrations of 1200, 781, or 273 ppm in a 32-L leach chamber for 4 h. Time-course samples for 1200 ppm and end-of-exposure samples for 781 and 273 ppm decane exposures were collected from blood, brain, liver, fat, bone marrow, lung, skin, and spleen. The pharmacokinetics of decane could not be described by flow-limited assumptions and measured in vitro tissue/air partition coefficients. A refined PBPK model for decane was then developed using flow-limited (liver and lung) and diffusion-limited (brain, bone marrow, fat, skin, and spleen) equations to describe the uptake and clearance of decane in the blood and tissues. Partition coefficient values for blood/air and tissue/blood were estimated by fitting end-of-exposure pharmacokinetic data and assumed to reflect the available decane for rapid exchange with blood. PBPK model predictions were adequate in describing the tissues and blood kinetics. For model validation, the refined PBPK model for decane had mixed successes at predicting tissue and blood concentrations for lower concentrations of decane vapor, suggesting that further improvements in the model may be necessary to extrapolate to lower concentrations.
The blood/air partition coefficient value was sensitive for predicting blood, brain, and lung decane concentrations. The lung/blood partition coefficient value was sensitive for predicting lung decane concentration. The blood and lung decane concentrations were sensitive to the bone marrow permeability area cross product, ventilation rate, and body weight. The model-predicted brain concentrations of decane were sensitive to the body weight brain/blood partition coefficient value, the permeability-area cross product for the brain, and the volume of the brain.
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