Registration Dossier
Registration Dossier
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EC number: 266-340-9 | CAS number: 66402-68-4 This category encompasses the various chemical substances manufactured in the production of ceramics. For purposes of this category, a ceramic is defined as a crystalline or partially crystalline, inorganic, non-metallic, usually opaque substance consisting principally of combinations of inorganic oxides of aluminum, calcium, chromium, iron, magnesium, silicon, titanium, or zirconium which conventionally is formed first by fusion or sintering at very high temperatures, then by cooling, generally resulting in a rigid, brittle monophase or multiphase structure. (Those ceramics which are produced by heating inorganic glass, thereby changing its physical structure from amorphous to crystalline but not its chemical identity are not included in this definition.) This category consists of chemical substances other than by-products or impurities which are formed during the production of various ceramics and concurrently incorporated into a ceramic mixture. Its composition may contain any one or a combination of these substances. Trace amounts of oxides and other substances may be present. The following representative elements are principally present as oxides but may also be present as borides, carbides, chlorides, fluorides, nitrides, silicides, or sulfides in multiple oxidation states, or in more complex compounds.@Aluminum@Lithium@Barium@Magnesium@Beryllium@Manganese@Boron@Phosphorus@Cadmium@Potassium@Calcium@Silicon@Carbon@Sodium@Cerium@Thorium@Cesium@Tin@Chromium@Titanium@Cobalt@Uranium@Copper@Yttrium@Hafnium@Zinc@Iron@Zirconium
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 5 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Justification for classification or non-classification
Based on the composition of the substance and the lack of bioavailability, the acute toxicity after oral and dermal exposure can be estimated as higher than 2,000 mg/kg.
The inhalation exposure of rats to comparable "SPINEL" at the maximal technically feasible concentration of 3.5 mg/L did not produce signs of toxicity. All animals survived and no adverse effects were observed during the 14-day observation period. Histologically rests of the test substance and borderline signs of tissue damage were seen.
With respect to inhalation toxicity LC50of "SPINEL" for male and female rats is therefore greater than 3.5 mg per litre air which is the highest technically feasible dust concentration.
Due to lack any signs of toxicity at 3.5 mg/L, LC50of "SPINEL" after inhalation is considered to be higher than 5 mg/l, which represents the limit for classification the substance as toxic.
Applying read-across it can be assumed that the LC50 for acute inhalation of Pleonaste is also greater than 5 mg/L and the substance can also be classified as practically non-toxic.
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