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EC number: 266-340-9
CAS number: 66402-68-4
This category encompasses the various chemical substances manufactured in the production of ceramics. For purposes of this category, a ceramic is defined as a crystalline or partially crystalline, inorganic, non-metallic, usually opaque substance consisting principally of combinations of inorganic oxides of aluminum, calcium, chromium, iron, magnesium, silicon, titanium, or zirconium which conventionally is formed first by fusion or sintering at very high temperatures, then by cooling, generally resulting in a rigid, brittle monophase or multiphase structure. (Those ceramics which are produced by heating inorganic glass, thereby changing its physical structure from amorphous to crystalline but not its chemical identity are not included in this definition.) This category consists of chemical substances other than by-products or impurities which are formed during the production of various ceramics and concurrently incorporated into a ceramic mixture. Its composition may contain any one or a combination of these substances. Trace amounts of oxides and other substances may be present. The following representative elements are principally present as oxides but may also be present as borides, carbides, chlorides, fluorides, nitrides, silicides, or sulfides in multiple oxidation states, or in more complex compounds.@Aluminum@Lithium@Barium@Magnesium@Beryllium@Manganese@Boron@Phosphorus@Cadmium@Potassium@Calcium@Silicon@Carbon@Sodium@Cerium@Thorium@Cesium@Tin@Chromium@Titanium@Cobalt@Uranium@Copper@Yttrium@Hafnium@Zinc@Iron@Zirconium
Justification for read-across:
Spinel type minerals all have a spinel crystal structure, no water
solubility and high melting points. Their behaviour in water and
biological systems is dominated by their insolubility and missing
bioavailability. They constitute in general practically inert materials
also with regard to their content of metal ions. Thus, they to not
contribute to any ecological hazards. They are also not bioavailable in
vivo, which was confirmed by solubility tests in surfactant and
stomach/small intestine fluids. The Spinel type minerals are not skin
irritating and not eye irritating in the conducted in vitro tests.
Physico-chemical properties of Spinel and Pleonaste:
The inhalation exposure of rats to"SPINEL"at the maximal
technically feasible concentration of 3.5 mg/L did not produce signs of
toxicity. All animals survived and no adverse effects were observed
during the 14-day observation period. Histologically rests of the test
substance and borderline signs of tissue damage were seen.
The LC50, per inhalation, four hours exposure, of "SPINEL" for
male and female rats is therefore greater than 3.5 mg per litre air
which is the highest technically feasible dust concentration.
Applying read-across it can be assumed that the LC50 for acute
inhalation of Pleonaste is greater than 3.5 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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