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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Meets generally accepted scientific standards, well documented and acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Range-Finding Toxicity Data: List IV
Author:
Smyth HF, Carpenter CP, Weil CS
Year:
1951
Bibliographic source:
Arch.Ind.Hyg.Occup.Med. 4: 119-122

Materials and methods

Principles of method if other than guideline:
Single oral dose toxicity is estimated by the gastric intubation of groups of five nonfasted, Carworth-Wistar male rats, four to five weeks of age and 90 to 120 grams in weight which have been reared in our own colony and maintained from time of weaning on Rockland rat diet, complete. The dosages are arranged in a logarithmic series differing by a factor of two. Whenever possible, the chemical is administered undiluted. When a lesser concentration is necessary, solution in water or corn oil or suspensions in semi-solid agar are the preferred expedients. Occasionally, a 1% solution of TERGITOL Penetrant 7 (essentially an aqueous solution of 25% sodium 3,9-diethyl-6-tridecanol sulfate) has been used as a dispersing agent. Based upon mortalities during a 14-day observation period, the most probable LD50 value and its fiducial range are estimated by the method of Thompson using the Tables of Weil.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Isoquinoline
EC Number:
204-341-8
EC Name:
Isoquinoline
Cas Number:
119-65-3
Molecular formula:
C9H7N
IUPAC Name:
isoquinoline
Details on test material:
- Name of test material (as cited in study report): Iso quinoline
no further data

Test animals

Species:
rat
Strain:
Wistar
Sex:
male
Details on test animals or test system and environmental conditions:
Nonfasted, Carworth-Wistar male rats, four to five weeks of age and 90 to 120 grams in weight which have been reared in our own colony and maintained from time of weaning on Rockland rat diet, complete.

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Details on oral exposure:
no data
Doses:
The dosages are arranged in a logarithmic series differing by a factor of two.
No. of animals per sex per dose:
5 males per dose
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
no further data
Statistics:
The most probable LD50 value and its fiducial range are estimated by the method of Thompson using the Tables of Weil.

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
360 mg/kg bw
Based on:
test mat.
Mortality:
no data
Clinical signs:
no data
Body weight:
no data
Gross pathology:
no data
Other findings:
no data

Applicant's summary and conclusion