Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 244-343-6 | CAS number: 21351-39-3
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
In a dermal sensitization study (OECD 429, GLP) with aduct urea-sulfuric (uronium hydrogen sulphate) in acetone/olive oil (4:1 v/v), young NMRI mices (6 females per dose) were tested using the method of LLNA (IMDS test) at concentrations of 25, 50 and 100% (v/v).
In contrast to the information known on the substance (i.e. no irritation by skin contact in the rabbit, no irritation observed in the acute oral and dermal test) a severe irritant effect of the test item Aduct urea-sulfuric was revealed.
This irritant effect is probably due to the used of a solvent (acetone/olive oil), that promotes penetration of the test item through the skin barrier.
Based on this study and the lack of sensitizing properties of its degradation products (urea and sulfates), Uronium hydrogen sulphate is not considered as a sensitizer to the skin.
Migrated from Short description of key information:
Uronium hydrogen sulphate is considered as not sensitising to the skin, but a non-specific (irritant) effect was observed during the test.
Justification for classification or non-classification
Data are conclusive for skin sensitisation, but not sufficient for classification according to CLP criteria (Regulation (EC) No 1272/2008). No classification is proposed for skin sensitisation according to CLP.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
