p-cumenesulphonic acid

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

supporting study

Study period:

1968-04-23

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Comparable to the OECD Guideline, Pre GLP study. Not a full study report.

Justification for data waiving:

other:

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1968

Report date:

1968

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Deviations:

yes

Remarks:

6 animals were used for study instead of 10 (5 male and 5 female animals)

Principles of method if other than guideline:

None

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Sodium Cumene Sulphonate

IUPAC Name:

Sodium Cumene Sulphonate

Details on test material:

- Name of test material (as cited in study report): Sodium Cumene Sulphonate
- Molecular formula (if other than submission substance): C9-H12-O3-S.Na
- Molecular weight (if other than submission substance): Not available
- Substance type: Pure active substance
- Physical state: Not available
- Analytical purity: See below
- Impurities (identity and concentrations): See below
- Composition of test material, percentage of components: See below
- Isomers composition: See below
- Purity test date: See below
- Lot/batch No.: See below
- Expiration date of the lot/batch: See below
- Stability under test conditions: Not available
- Storage condition of test material: Not available
- Other: None

Test animals

Species:

rabbit

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Not available
- Age at study initiation: Not available
- Weight at study initiation: 2703 grams (Abraded skin), 2730 grams (Intact skin)
- Fasting period before study: Not available
- Housing: Not available
- Diet (e.g. ad libitum): Not available
- Water (e.g. ad libitum): Not available
- Acclimation period: Not available


ENVIRONMENTAL CONDITIONS
- Temperature (°C): Not available
- Humidity (%): Not available
- Air changes (per hr): Not available
- Photoperiod (hrs dark / hrs light): Not available


IN-LIFE DATES: 1968-04-23

Administration / exposure

Type of coverage:

not specified

Vehicle:

not specified

Details on dermal exposure:

TEST SITE
- Area of exposure: Not available
- % coverage: Not available
- Type of wrap if used: Not available


REMOVAL OF TEST SUBSTANCE
- Washing (if done): Not available
- Time after start of exposure: Not available


TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2 ml/kg bw
- Concentration (if solution): Not available
- Constant volume or concentration used: yes
- For solids, paste formed: Not available


VEHICLE
- Amount(s) applied (volume or weight with unit): Not available
- Concentration (if solution): Not available
- Lot/batch no. (if required): Not available
- Purity: Not available

Duration of exposure:

Not available

Doses:

2000 mg/kg bw

No. of animals per sex per dose:

Total 6 animals were taken for the study. Sex was not mentioned.

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Not available
- Necropsy of survivors performed: Not available
- Other examinations performed: Clinical signs, body weight

Statistics:

None

Results and discussion

Preliminary study:

None

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Mortality:

0/3 (Abraded skin), 0/3 (Intact skin)

Clinical signs:

other: Sodium Cumene Suphonate elicited moderate primary irritation on the test sites.

Gross pathology:

Not available

Other findings:

- Organ weights: None
- Histopathology: None
- Potential target organs: None
- Other observations: None

Any other information on results incl. tables

None

Applicant's summary and conclusion

Interpretation of results:

practically nontoxic

Remarks:

Migrated information Criteria used for interpretation of results: OECD GHS

Conclusions:

The LD50 > 2000 mg/kg bw and test substance is considered practically non toxic.

Executive summary:

The LD50 was >2000 mg/kg bw. This test substance is practically non toxic.