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EC number: 204-683-8 | CAS number: 124-13-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Not compliant with any guidelines or GLP, but endpoint sufficient for hazard classification purposes.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 962
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The test substance was administered to male rats in a single dose via oral gavage to determine toxicity. The assays included in the paper are all intended to provided initial screening information and so do not comply with the requirements of test guidelines subsequently published
- GLP compliance:
- no
- Remarks:
- conducted prior to adoption of GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1-Octanal
- IUPAC Name:
- 1-Octanal
- Reference substance name:
- Octanal
- EC Number:
- 204-683-8
- EC Name:
- Octanal
- Cas Number:
- 124-13-0
- Molecular formula:
- C8H16O
- IUPAC Name:
- octanal
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): 1-Octanal
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- other: Carworth-Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Mellon Institute
- Age at study initiation: 4 to 5 weeks of age
- Weight at study initiation: 90 to 120 grams
- Fasting period before study: No fasting period as test animals were non-fasted on administration of the test substance.
- Housing: Not documented
- Diet (e.g. ad libitum): Rockland rat diet, complete, ad libitum
- Water (e.g. ad libitum): Not documented
- Acclimation period: Not documented
ENVIRONMENTAL CONDITIONS
No details provided in publication
IN-LIFE DATES: No details provided in publication
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: Not documented, although the dosages are arranged in a logarithmic series differing by a factor of 2.
DOSAGE PREPARATION (if unusual): No information provided for octanal. Where lower concentrations were required the test material was diluted with water, corn oil or semi-solid agar. - Doses:
- Not documented, although the dosages are arranged in a logarithmic series differing by a factor of 2.
- No. of animals per sex per dose:
- 5 male rats
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: No information provided
- Necropsy of survivors performed: no data
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: no data - Statistics:
- No information provided
Results and discussion
- Preliminary study:
- Not relevant
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 5.63 mL/kg bw
- Based on:
- not specified
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 4 617 mg/kg bw
- Remarks on result:
- other: The mg/kg dose was estimated based on the Specific Gravity value of 0.82 g/mL
- Mortality:
- No mortalities were observed.
- Clinical signs:
- other: No information provided
- Gross pathology:
- No information provided
- Other findings:
- No additional information provided
Any other information on results incl. tables
No information provided
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of this study, the LD50 for octanal was calculated to be 5.63 ml/kg bw, which is equivalent to 4617 mg/kg bw. Based on this result, the test substance does not warrant any classification in accordance with Regulation EC No. 1272/2008.
- Executive summary:
In a study conducted by Smyth et al, (1962), the test substance 1-Octanal, was examined for its ability to cause acute toxicity when administered via oral gavage. The test substance was administered to 5 male non-fasted Carworth-Wistar rats in dosages administered in a logarithmic series differing by a factor of 2. The test animals were observed for 14 days following administration. Under the conditions of this study, the LD50 of the test substance was determined to be 5.63 ml/kg bw which is equivalent to 4617 mg/kg bw. Based on this result, 1-octanal does not warrant any classification for acute oral toxicity in accordance with Regulation EC No. 1272/2008.
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