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EC number: 204-683-8 | CAS number: 124-13-0
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Not compliant with any guidelines or GLP; endpoint sufficient for hazard classification.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 962
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The test substance was applied to test sites on the shaved trunk of New Zealand White albino rabbits for an exposure period of 24 hours.
The assays included in the paper are all intended to provided initial screening information and so do not comply with the requirements of test guidelines subsequently published - GLP compliance:
- no
- Remarks:
- conducted prior to adoption of GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1-Octanal
- IUPAC Name:
- 1-Octanal
- Reference substance name:
- Octanal
- EC Number:
- 204-683-8
- EC Name:
- Octanal
- Cas Number:
- 124-13-0
- Molecular formula:
- C8H16O
- IUPAC Name:
- octanal
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): 1-Octanal
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Not documented
- Age at study initiation: Not documented
- Weight at study initiation: 2.5 to 3.5kg
- Fasting period before study: Not documented
- Housing: Not documented
- Diet (e.g. ad libitum): Not documented
- Water (e.g. ad libitum): Not documented
- Acclimation period: Not documented
ENVIRONMENTAL CONDITIONS
No details provided in publication
IN-LIFE DATES: No details provided in publication
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Entire trunk shaved free of hair
- % coverage: Not documented
- Type of wrap if used: Impervious plastic film
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): Up to 20 ml/kg can be aplied by this method but greater volumes cannot be retained suitably on the dorsum - Duration of exposure:
- The test animals were exposed to the test substance for a 24 hour contact period.
- Doses:
- Up to 20 ml/kg
- No. of animals per sex per dose:
- 4 male test animals
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Not documented
- Necropsy of survivors performed: Not documented
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: Not documented - Statistics:
- No information provided
Results and discussion
- Preliminary study:
- Not relevant
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 6.35 mL/kg bw
- Based on:
- test mat.
- 95% CL:
- > 4.7 - < 8.59
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 5 207 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No information provided
- Clinical signs:
- other: No information provided
- Gross pathology:
- No information provided
- Other findings:
- No information provided
Any other information on results incl. tables
No additional information provided
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of this study, the LD50 of 1-Octanal, was determined to be 6.35 ml/kg bw which is equivalent to 5207 mg/kg bw . Based on this result, the test substance does not warrant any classification in accordance with Regulation EC No. 1272/2008.
- Executive summary:
In a study conducted by Smyth et al (1962) 1-Octanal, was tested for its ability to cause acute dermal toxicity when applied to male New Zealand White albino rabbits. The entire trunk of each test animal was shaved prior to application of the test material and the test substance was applied. An impervious dressing was applied to the test site and remained in place for the 24 hours exposure period. During this exposure period, the test animals were placed in restraint tubes. Following exposure, the test animals were placed in cages for the 14 day observation period. Under the conditions of this study, the LD50 of 1-Octanal, was determined to be 6.35 ml/kg bw, equivalent to 5207 mg/kg bw. Based on this result, the test substance does not warrant classification for acute dermal toxicity in accordance with Regulation EC No. 1272/2008.
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