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EC number: 204-683-8
CAS number: 124-13-0
Groups of 15 male and 15 female rats were fed for at least 90 days on
diets that provided 2,6 -dimethylhept-5 -en·l-al (DMH) at average
intakes of 0 (control), 9, 37 and 150 mg/kg bw/day. Steps were taken to
limit loss of DMH during diet mixing, storage and feeding. No effects
attributable to treatment were encountered in body weight, food intake,
water intake, haematology (at wk 6 and 13) or the gross and microscopic
pathological examinations. At the highest dose level there was a slight
reduction in renal concentrating ability at week 6 in males and week 14
in females, together with a small increase in relative kidney and liver
weights in females. The serum-glucose concentrations of both sexes on
the highest dose were elevated compared with the controls. It was
concluded that the intermediate dose, providing an intake of 37
mg/kg/day, was the NOAEL.
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