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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
25 February 2013 – 28 February 2013
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
GLP compliant study in compliance with international recognized guidelines.
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
2008
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
1995
Deviations:
no
GLP compliance:
yes
Type of method:
flask method
Water solubility:
1.1 g/L
Temp.:
10 °C
pH:
> 5 - < 6.9
Remarks on result:
other: standard deviation: 0.026, replicates of three days
Water solubility:
1.4 g/L
Temp.:
20 °C
pH:
> 4.8 - < 5.8
Remarks on result:
other: standard deviation: 0.008, replicates of three days
Details on results:
The difference between the concentrations of the test substance of day 1 to 3 at 10 °C and 20 °C was <15 % and the concentrations of the test substance showed no relevant tendency. Therefore the mean of day 1 - 3 was taken as the solubility of the test substance at both temperatures, according to the guidelines.

As the temperature coefficient of the solubility of the test substance was <3 % (i.e. 2.8 %) per °C, the solubility was not determined at three temperatures, in agreement with the guideline.
Conclusions:
Interpretation of results (migrated information): soluble (1000-10000 mg/L)
The water solubility of the test substance is 1.4 ± 0.008 g/L at 20ºC.
Executive summary:

Following the flask method detailed within OECD 105, the solubility of the test substance was determined to be 1.4 ± 0.008 g/L (1400 mg/L) at 20ºC based on the mean of day 1 – 3. As the temperature coefficient of the solubility of the test substance was <3% (i.e. 2.8%) per ºC, the solubility was not determined at three temperatures.

Description of key information

The water solubility of the test substance is 1.4 ± 0.008 g/L at 20ºC.

Key value for chemical safety assessment

Water solubility:
1 400 mg/L
at the temperature of:
20 °C

Additional information

Following the flask method detailed within OECD 105, the solubility of the test substance was determined to be 1.4 ± 0.008 g/L (1400 mg/L) at 20ºC based on the mean of day 1 – 3. As the temperature coefficient of the solubility of the test substance was <3% (i.e. 2.8%) per ºC, the solubility was not determined at three temperatures.