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EC number: 241-749-5 | CAS number: 17766-26-6
Toxicological information
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- no body weight determination
- Principles of method if other than guideline:
- No reference to OECD guideline is made in the report.
- GLP compliance:
- no
- Remarks:
- study performed prior to implementation of GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1,3,5-triazine-2,4,6(1H,3H,5H)-trithione, trisodium salt
- EC Number:
- 241-749-5
- EC Name:
- 1,3,5-triazine-2,4,6(1H,3H,5H)-trithione, trisodium salt
- Cas Number:
- 17766-26-6
- Molecular formula:
- C3N3S3.3Na
- IUPAC Name:
- trisodium trisulfanylidene-1,3,5-triazinane-1,3,5-triide
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: males 44 - 49 days, females 57 - 63 days
- Weight at study initiation: males 127 - 147 g, females 128 - 148 g
- Fasting period before study: 16 h
- Housing: individually
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21°C +/-2°C
- Humidity (%): 50-60%
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- The following dose volumes of the test substance were applied: 4.64, 6.81 and 10 mL/kg bw
MAXIMUM DOSE VOLUME APPLIED: 10.0 mL/kg bw - Doses:
- 5197, 7627, 11200 mg/kg bw (related to product TMT 15)
equivalent to
780, 1144 and 1680 mg anhydrous TMT/kg bw
1418, 2080, 3055 mg TMT55/kg bw - No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: at 0.5, 1, 2, 4, 8, 24 h, 2 days after dosing and once daily thereafter
- Frequency of weighing: day 0 (prior to dosing)
- Necropsy of survivors performed: yes
- Other examinations performed: gross examination of organs at necropsy - Statistics:
- The LD50 value was calculated using the Probit Analysis.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 7 878 mg/kg bw
- Based on:
- test mat.
- Remarks:
- TMT 15
- 95% CL:
- 6 364 - 9 752
- Remarks on result:
- other: Probit analysis
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 182 mg/kg bw
- Based on:
- other: anhydrous form
- Remarks on result:
- other: recalculated value based on 15% TMT
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 149 mg/kg bw
- Based on:
- other: hydrated form (TMT 55)
- Remarks on result:
- other: calculated value for TMT 55
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 11 200 mg/kg bw
- Based on:
- test mat.
- Remarks:
- TMT 15
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 1 680 mg/kg bw
- Based on:
- other: anhydrous form
- Remarks on result:
- other: recalculated value based on 15% TMT
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 3 055 mg/kg bw
- Based on:
- other: hydrated form (TMT 55)
- Remarks on result:
- other: calculated value for TMT 55
- Mortality:
- All mortalities occurred between 4 h and 2 days after administration.
males: 0/5 at 5197 mg TMT 15/kg bw, 2/5 at 7627 mg TMT 15/kg bw, 5/5 at 11200 mg TMT 15/kg bw
females: 0/5 at 5197 mg TMT 15/kg bw, 1/5 at 7627 mg TMT 15/kg bw, 2/5 at 11200 mg TMT 15/kg bw - Clinical signs:
- other: No clinical signs were noted in animals receiving the lowest dose. Piloerection, laboured respiration, increased pain perception, stilted gait and clonic convulsions were observed in rats administered the mid and high dose.
- Gross pathology:
- Accumulation of reddish-brown fluid in the stomach was observed in animals that died as well as in animals that were sacrificed at the end of the study. No further effects were noted in any of the organs at necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified for the test substance TMT 15, Toxicity Category V (OECD GHS) for TMT 55, Toxicity Category IV for anhydrous TMT
- Remarks:
- Criteria used for interpretation of results: OECD GHS
- Conclusions:
- In this acute oral toxicity study with TMT 15 the obtained LD50 values were 7878 mg/kg bw (corresponding to 1182 mg anhydrous TMT/kg bw) for male rats and >11200 mg/kg bw (corresponding to > 1680 mg anhydrous TMT/kg bw) for female rats.
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