N,N-diethylaniline

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from authoritative database

Data source

Reference

Reference 1

Reference Type:

review article or handbook

Title:

Acute oral toxicity of test chemical

Author:

Lenga, R. E.

Year:

1988

Bibliographic source:

The Sigma-Aldrich Library of Chemical Data 2nd ed., 1988, Sigma Aldrich, Milwaukee, WI.

Reference 2

Reference Type:

review article or handbook

Title:

DPIM: DIS700

Author:

Richard J. Lewis, Sr.

Year:

2007

Bibliographic source:

SAX (Sax's Handbook of Dangerous Industrial Materials):-Personal Communication from Josef V. Marhold, VUOS, 539-18, Pardubice, Czechoslovakia, to the Editor of RTECS, Cincinnati, OH, March 29, 1977 29MAR77.

Reference 3

Reference Type:

review article or handbook

Title:

D291

Author:

RSC Publishing

Year:

2011

Bibliographic source:

Dictionary of Substances and their effects (DOSE):-Lenga, R. E. The Sigma-Aldrich Library of Chemical Data 2nd ed., Sigma Aldrich, Milwaukee, WI;1988

Reference 4

Reference Type:

other: authoritative database

Title:

Acute Toxicity studies conducted on rodents

Author:

U.S. National Library of Medicine

Year:

2018

Bibliographic source:

HSDB

Reference 5

Reference Type:

other: Secondary source

Title:

Acute toxicity of test chemical

Author:

EUROPEAN COMMISSION – European Chemicals Bureau

Year:

2000

Bibliographic source:

IUCLID Dataset, EUROPEAN COMMISSION – European Chemicals Bureau, 18 – FEB - 2000

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: As mentioned below

Principles of method if other than guideline:

Acute oral toxicity of test chemical in rats

GLP compliance:

not specified

Test type:

standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

N,N-diethylaniline

EC Number:

202-088-8

EC Name:

N,N-diethylaniline

Cas Number:

91-66-7

Molecular formula:

C10H15N

IUPAC Name:

N,N-diethylaniline

Test material form:

liquid

Remarks:

Oily liquid

Details on test material:

- Name of test material (as cited in study report): N,N-Diethylaniline
- Molecular formula: C10-H15-N
- Molecular weight: 149.236 g/mol
- Smiles notation: c1(N(CC)CC)ccccc1
- InChl: 1S/C10H15N/c1-3-11(4-2)10-8-6-5-7-9-10/h5-9H,3-4H2,1-2H3
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

not specified

Details on oral exposure:

not reported

Doses:

782 mg/kg bw

No. of animals per sex per dose:

not reported

Control animals:

not specified

Details on study design:

not reported

Statistics:

not reported

Results and discussion

Preliminary study:

not reported

Effect levels

Key result

Sex:

not specified

Dose descriptor:

LD50

Effect level:

782 mg/kg bw

Based on:

test mat.

Remarks on result:

other:

Remarks:

50% mortality observed

Mortality:

50% mortality observed at 782 mg/kg bw dose

Clinical signs:

other: not reported

Gross pathology:

not reported

Other findings:

not reported

Applicant's summary and conclusion

Interpretation of results:

Toxicity Category IV

Conclusions:

The Lethal concentration value for 50 percent mortality (LD 50) in rats by the oral administration of test chemical was reported to be 782 mg/kg body weight.

Executive summary:

Acute oral toxicity study of test chemical was conducted on rats at the dose concentration of 782 mg/kg bw. The test chemical was administered via oral unspeciified route. All animals were maintained under close observation for recording toxic signs and time of death for 14 days. 50% mortality was observed at 782 mg/kg bw. Therefore, LD50 value was considered to be 782 mg/kg bw, when rats were treated with test chemical via oral route..