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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from publication

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
1992

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute inhalation toxicity of test chemical in mice
GLP compliance:
not specified
Test type:
fixed concentration procedure
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
N,N-diethylaniline
EC Number:
202-088-8
EC Name:
N,N-diethylaniline
Cas Number:
91-66-7
Molecular formula:
C10H15N
IUPAC Name:
N,N-diethylaniline
Test material form:
liquid
Details on test material:
- Name of test material (as cited in study report): N,N-Diethylaniline
- Molecular formula: C10-H15-N
- Molecular weight: 149.236 g/mol
- Smiles notation: c1(N(CC)CC)ccccc1
- InChl: 1S/C10H15N/c1-3-11(4-2)10-8-6-5-7-9-10/h5-9H,3-4H2,1-2H3
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
male
Details on test animals or test system and environmental conditions:
Not available

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
head only
Vehicle:
not specified
Details on inhalation exposure:
Details not available
Duration of exposure:
4 h
Concentrations:
533ppm, 644 ppm, 782 ppm, and 923 ppm
No. of animals per sex per dose:
10 male rats each dose.
Control animals:
not specified
Details on study design:
Not specified
Statistics:
Not specified

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LC50
Effect level:
4.14 mg/L air
Based on:
test mat.
Exp. duration:
4 h
Remarks on result:
other: 679 ppm equal to 4144.538 mg/m3
Mortality:
533 ppm (2/10), 644 ppm (6/10), 782ppm (5/10), AND 923ppm (9/10).
Clinical signs:
other: CLINICAL SIGNS DURING AND IMMEDIATELY AFTER EXPOSURE INCLUDED: CYANOSIS, TREMORS, SEMIPROSTRATION, REDDISHBROWN NASAL DISCHARGE, HIND IMB ATAXIA, SALIVATION, AND ABNORMAL ARCHED BACK POSTURE. SIGNS OBSERVED AFTER 24 HOURS INCLUDED: STAINED PERINEAL AREA,
Body weight:
WEIGHT LOSS WAS OBSERVED 13 DAYS AFTER EXPOSURE; THEREAFTER NORMAL WEIGHT GAIN WAS SEEN.
Gross pathology:
Not specified
Other findings:
Not specified

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category III
Conclusions:
Acute inhalation toxicity in male rats was reported to be 679 ppm(4144.538 mg/m3 =4.144 mg/L).
Executive summary:
Acute inhalation toxicity for test chemical was studied in male rats. male rats(head only) were exposed for a single 4 hour period at a concentration of 533ppm, 644 ppm, 782 ppm, and 923 ppm. Clinical signs during and immediately after exposure included cyanosis, tremors, semi prostration, reddish brown nasal discharge, hind limb ataxia, salivation, and abnormal arched back posture. Signs observed after 24 hours included: stained perineal area, pallor, and reddish brown nasal discharge. Thus, LC 50 value was reported to be 679 ppm(4144.538 mg/m3=4.144 mg/l)