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Physical & Chemical properties

Water solubility

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Endpoint:
water solubility
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
2017
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Qualifier:
no guideline required
Principles of method if other than guideline:
The water solubility was calculated using the OPERA calculation model.
Water solubility:
4.64 other: mol/L
Remarks on result:
other: This is a calculation conducted using the OPERA calculation model. As such, the information on Temperature, pH can not be filled in.
Conclusions:
The water solubility of pure choline hydroxide was calculated to be 4.64 mol/L.
Executive summary:

The water solubility of pure choline hydroxide was calculated with OPERA Model calculation. The water solubility was calculated to be 4.64 mol/L.

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2013-03-11
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: well-documented study (preliminary test / OECD 105 guideline) without deviations
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to same study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
GLP compliance:
no
Type of method:
other: visual inspections
Water solubility:
> 90 vol%
Temp.:
22 °C
pH:
14.2
Remarks on result:
other: Referring to a 45 % aqueous solution of choline hydroxide; the test item was confirmed as fully miscible
Water solubility:
> 486 g/L
Temp.:
22 °C
pH:
> 14.2
Remarks on result:
other: recalculated via the density of the 45 % solution, which was possible because the test item did not reveal any precipitation from visual inspection

Table 1: All test solution weighings, measurements and observations  












































































Wt sample (g)



Soluble?



% w/w



Miscible?



pH



1.0019



9.0145



10.00



Yes



13.10



2.0218



8.0179



20.14



Yes



13.35



3.0082



7.0246



29.98



Yes



13.51



4.0043



6.0252



39.93



Yes



13.62



5.0325



5.0037



50.14



Yes



13.73



6.0116



4.0157



59.95



Yes



13.83



7.0120



3.0171



69.92



Yes



13.94



8.0046



2.0251



79.81



Yes



14.06



9.0044



1.0001



90.00



Yes



14.20



 


pH of distilled water blank = 7.72


 


In addition the test substance and all test solutions were observed to contain no precipitate.


 


The water solubility oftest substance Choline Base was confirmed as miscible in all proportions as a 45 weight % solution in water. It is therefore reasonable to calculate the water solubility of Choline Base assuming that the test substance is fully soluble in water as a 45 weight % solution in water:


 


45 weight % is equivalent to 450 g/kg x 1.08 kg/L (Density of Test Solution) = 486 g/Litre.


 


This will be reported as a minimum solubility value of >486 g/Litre.

Conclusions:
Interpretation of results: very soluble (> 10000 mg/L)
The test substance and all test solutions were observed to contain no precipitate.

The water solubility of test substance Choline Base (as a 45 % aqueous solution) was confirmed as miscible in all proportions. It is therefore reasonable to calculate the water solubility of Choline Base assuming that the test substance is fully soluble in water as a 45 weight % solution in water:

45 weight % is equivalent to 450 g/kg x 1.08 g/L (Density of Test Solution) = 486 g/Litre.

This will be reported as a minimum solubility value of >486 g/Litre.
Executive summary:

The water solubility of a 45 % choline hydroxide (CB) solution was determined in a OECD 105 guideline study by visual inspection. All tested proportions ranging from 1:9 to 9:1 were reported fully miscible and no phase separation occured. Also, choline base as a 45 % solution did not exhibit any visual precipitation. This allows the conclusion that the water solubility of choline hydroxide is > 486 g CB / 1L water, so choline hydroxide is very soluble.

Description of key information

Water solubility (study conducted using a 45 % Choline hydroxide aqueous solution): very soluble, approx. ≥ 486 g Choline hydroxide / 1L water (according OECD 105, visual inspection)


Water solubility (pure choline hydroxide) calculated with OPERA Model: 4.64 mol/L.

Key value for chemical safety assessment

Water solubility:
486 g/L
at the temperature of:
22 °C

Additional information

The water solubility of a 45 % Choline hydroxide (CB) solution was determined in an OECD 105 guideline study by visual inspection. All tested proportions ranging from 1:9 to 9:1 were reported fully miscible and no phase separation occured. Also, Choline base as a 45 % solution did not exhibit any visual precipitation. This allows the conclusion that the water solubility of Choline hydroxide is > 486 g CB / 1L water, so Choline hydroxide can be considered as very soluble in further risk assessment.


The test was performed according OECD 105 guideline and the study is classified as Klimisch 1. The results are reasonable, within the scientifically expected ranges and can therefore be considered as reliable. Hence, the tonnage-driven data requirements under REACH are fully met, no datagaps were identified and no further testing is required.


 


In addition, the water solubility of pure choline hydroxide was calculated with OPERA Model calculation. The water solubility was calculated to be 4.64 mol/L.