Registration Dossier
Registration Dossier
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EC number: 204-625-1 | CAS number: 123-41-1
Endpoint summary
Administrative data
Description of key information
Additional information
The potential for bioaccumulation in aquatic organisms (most likely in fish) was not determined experimentally for Choline hydroxide. Based on the intrinsic properties of the test substance (i.e. logPow of -2.25 at 25 °C; Intertek, 2013), this study can be waived in accordance to REACH, Annex IX, Section 9.3.2, column 2. Since the Bioconcentration Factor (BCF) is an important parameter for the chemical safety assessment of the substance, the EPIWIN software BCFBAF v3.01 was used to determine this value for Choline hydroxide (Chemservice S.A., 2013, updated 2019). Using the regression-based estimate (traditional method) a BCF of 3.16 L/kg wet-wt was predicted. Using the Arnot-Gobas method, which is based on mechanistic first principles, an aquatic BCF of 0.89 L/kg wet-wt is the result. These results confirm that bioaccumulation in aquatic organisms is unlikely.
Also terrestrial bioaccumulation of Choline hydroxide is not expected. However, no information is available and this endpoint is no mandatory requirement under REACH.
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