Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 220-260-0 | CAS number: 2691-41-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 23 to 30 July 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study run to a reliable method but not to GLP and no guideline followed
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Three male and three female rabbits were tested in this study. The test substance placed in to the right eye, the other eye remained untreated to serve as a control. The ocular reaction was recorded at 1 h, 24 h and 2, 3 and 7 days after treatment.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine
- EC Number:
- 220-260-0
- EC Name:
- Octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine
- Cas Number:
- 2691-41-0
- Molecular formula:
- C4H8N8O8
- IUPAC Name:
- 1,3,5,7-tetranitro-1,3,5,7-tetrazocane
- Test material form:
- solid: crystalline
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Cheshire Rabbits Farms
- Weight at study initiation: 2.5-3.0 kg
- Housing: They were housed individually in cages with a grid floor, beneath which was a peat moss filled tray.
- Diet (e.g. ad libitum): The animals were fed on Spratt's Rabbit Diet, ad libitum.
- Water (e.g. ad libitum): Water was allowed ad libitum.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21°C (extremes of 16°C-23°C)
- Humidity (%): 65% (extremes of 60%-78%)
No additional data
Test system
- Vehicle:
- water
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL
No additional data - Duration of treatment / exposure:
- 7 days
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 3 male and 3 female
- Details on study design:
- SCORING SYSTEM: Draize
TOOL USED TO ASSESS SCORE: The eyes were examined for irritation using standard illumination.
No additional data
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: Mean of 24, 48 and 72 hours
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: Mean of 24, 48 and 72 hours
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: Mean of 24, 48 and 72 hours
- Score:
- 0
- Max. score:
- 1
- Reversibility:
- fully reversible within: 24 hours
- Remarks on result:
- other: One treated eye showed slight redness at 7 days.
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: Mean of 24, 48 and 72 hours
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- ca. 0
- Max. score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- ca. 0
- Max. score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- ca. 0
- Max. score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- ca. 0
- Max. score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Score:
- ca. 0
- Max. score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- ca. 0
- Max. score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- The test material elicited no corneal or iridial response at any stage of the test.
Slight redness of the conjunctivae was noted in 2/6 treated eyes at 1 h. One treated eye showed slight redness at 7 days. 5/6 treated eyes had returned to normal at 24 h. - Other effects:
- Test material was evident as aggregations in the inner corner of the eye at 1 h in all treated eyes and in 1/6 treated eyes at 24 h.
Any other information on results incl. tables
|
Scores |
||||||
Time after administration |
Rabbit No. and Sex |
7♂ |
8♀ |
9♂ |
10♀ |
11♂ |
12♀ |
1 hour |
Cornea |
0 |
0 |
0 |
0 |
0 |
0 |
Iris |
0 |
0 |
0 |
0 |
0 |
0 |
|
Conjunctivae redness |
1 |
0 |
0 |
0 |
0 |
1 |
|
Conjunctivae chemosis |
0 |
0 |
0 |
0 |
0 |
0 |
|
Conjunctivae discharge |
0 |
0 |
0 |
0 |
0 |
0 |
|
24 hours |
Cornea |
0 |
0 |
0 |
0 |
0 |
0 |
Iris |
0 |
0 |
0 |
0 |
0 |
0 |
|
Conjunctivae redness |
0 |
0 |
0 |
0 |
0 |
0 |
|
Conjunctivae chemosis |
0 |
0 |
0 |
0 |
0 |
0 |
|
Conjunctivae discharge |
0 |
0 |
0 |
0 |
0 |
0 |
|
48 hours |
Cornea |
0 |
0 |
0 |
0 |
0 |
0 |
Iris |
0 |
0 |
0 |
0 |
0 |
0 |
|
Conjunctivae redness |
0 |
0 |
0 |
0 |
0 |
0 |
|
Conjunctivae chemosis |
0 |
0 |
0 |
0 |
0 |
0 |
|
Conjunctivae discharge |
0 |
0 |
0 |
0 |
0 |
0 |
|
72 hours |
Cornea |
0 |
0 |
0 |
0 |
0 |
0 |
Iris |
0 |
0 |
0 |
0 |
0 |
0 |
|
Conjunctivae redness |
0 |
0 |
0 |
0 |
0 |
0 |
|
Conjunctivae chemosis |
0 |
0 |
0 |
0 |
0 |
0 |
|
Conjunctivae discharge |
0 |
0 |
0 |
0 |
0 |
0 |
|
7 days |
Cornea |
0 |
0 |
0 |
0 |
0 |
0 |
Iris |
0 |
0 |
0 |
0 |
0 |
0 |
|
Conjunctivae redness |
0 |
1 |
0 |
0 |
0 |
0 |
|
Conjunctivae chemosis |
0 |
0 |
0 |
0 |
0 |
0 |
|
Conjunctivae discharge |
0 |
0 |
0 |
0 |
0 |
0 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test substance is a mild irritant to eyes. However under the Regulatin (EC) No 1272/2008 it is not classified for eye irritation
- Executive summary:
Under the Regulatin (EC) No 1272/2008, the test substance tested as HMX in water, is not classified for skin irritation. As per the table below the mean score for corneal opacity or iritis wasn't ≥ 1 and/or conjunctival redness or oedema (chemosis) wasn't ≥ 2
calculated between the time points: 24, 48 and 72 hours.
Animal no
Mean scores at 24, 48 and 72 hrs)
Cornea
Iris
Conjunctivae
redness
chemosis
discharge
33
0
0
0.33
0
0
34
0
0
0.17
0
0
35
0
0
0
0
0
36
0
0
0
0
0
37
0
0
0.17
0
0
38
0
0
0.33
0
0
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
