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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Description of key information

Significant accumulation in organisms is not to be expected. 

Key value for chemical safety assessment

BCF (aquatic species):
4.9 L/kg ww

Additional information

QSAR-disclaimer:

In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met.

Furthermore, according to Article 25 of the same Regulation testing on vertebrate animals shall be undertaken only as a last resort.

According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.

For the assessment of dimethyl(propyl)amine (CAS 926-63-6) (Q)SAR results were used for aquatic bioaccumulation. The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment.

Therefore, and for reasons of animal welfare, further experimental studies on aquatic bioaccumulation are not provided.

 

Assessment:

According to Regulation (EC) 1907 (2006) Annex IX, section 9.3.2, column 2, a study on bioaccumulation does not need to be conducted as the substance has a low potential for bioaccumulation. Dimethyl(propyl)amine (CAS 926-63-6) has a log Kow of 1.32 (measured; BASF SE, 2013; study no. 11L00479).

A read across bioaccumulation study with the structurally similar substance triethylamine (CAS 121-44-8) indicates a low potential of bioaccumulation for dimethylpropylamine. The study was performed according to OECD 305C with Cyprinus carpio as a test species. The BCF was determined to be less or equal than 4.9 L/kg. (NITE, 1990).

The key study is supported by QSAR calculations of the target substance and three structurally similar substances. The table below lists the applied (Q)SAR model, the estimated BCF values and basic information on the applicability domain (AD). Detailed information on the model’s results and the AD are given in the endpoint study records of IUCLID Chapter 5.3.1. The selected model comply with the OECD principles for (Q)SAR models.

 

Predicted BCF values from applied QSAR model (AD = Applicability Domain)

Substance Model

BCF

In AD

Restraints

Target substance CAS 926-63-6

BCF baseline model v4.11 (OASIS Catalogic v5.14.1.5): incl. mitigating factors

2.7

yes

-

Target substance CAS 926-63-6

BCF baseline model v4.11 (OASIS Catalogic v5.14.1.5): mitigating factors not considered

 

18.8

yes

-

Source substance

CAS 927-62-8

BCF baseline model v4.11 (OASIS Catalogic v5.14.1.5): incl. mitigating factors

3.3

yes

-

Source substance

CAS 927-62-8

 

BCF baseline model v4.11 (OASIS Catalogic v5.14.1.5): mitigating factors not considered

22.3

yes

-

Source substance

CAS 598-56-1

 

BCF baseline model v4.11 (OASIS Catalogic v5.14.1.5): incl. mitigating factors

2.8

yes

-

Source substance

CAS 598-56-1

 

BCF baseline model v4.11 (OASIS Catalogic v5.14.1.5): mitigating factors not considered

11.9

yes

-

Source substance

CAS 121-44-8

 

 

BCF baseline model v4.11 (OASIS Catalogic v5.14.1.5): incl. mitigating factors

3.1

yes

-

Source substance

CAS 121-44-8

 

BCF baseline model v4.11 (OASIS Catalogic v5.14.1.5): mitigating factors not considered

21.2

yes

-

 

Based on the available calculated data for dimethyl(propyl)amine (CAS 926-63-6) and the read across data from the structurally similar substances N,N-dimethylbutylamine (CAS 927-62-8), ethyldimethylamine (CAS 598-56-1) and triethylamine (CAS 121-44-8), it can be concluded that significant accumulation in organisms is not to be expected.