Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
explosiveness
Type of information:
experimental study
Adequacy of study:
key study
Study period:
3.2.2005 - 9.2.2005
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP-Guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2005
Report date:
2005

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method A.14 (Explosive properties)
Deviations:
no
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
(3S,5S)-5-[(1S,3S)-1-azido-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-4-methylpentyl]-3-(propan-2-yl)oxolan-2-one
EC Number:
608-748-5
Cas Number:
324763-46-4
Molecular formula:
C25 H39 N3 O5
IUPAC Name:
(3S,5S)-5-[(1S,3S)-1-azido-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-4-methylpentyl]-3-(propan-2-yl)oxolan-2-one

Results and discussion

Small-scale preliminary testsopen allclose all
Parameter:
other: More sensitive to shock than m-dinitrobenzene
Remarks:
migrated information
Remarks on result:
negative (not further specified)
Parameter:
other: More sensitive to friction than m-dinitrobenzene
Remarks:
migrated information
Remarks on result:
negative (not further specified)
Parameter:
other: Explosive under influence of flame
Remarks:
migrated information
Remarks on result:
negative (not further specified)
Parameter:
other: Explosive (not specified)
Remarks:
migrated information
Remarks on result:
negative (not further specified)

Any other information on results incl. tables

Exposing test substance to thermal stress did not result in an explosion or vigorous reaction. None of the test tubes had burst into fragments.

When dropping 10 kg mass from 0.4 meter height on the test substance (mechanical sensitivity by shock), no (traces of) vigorous reactions were observed. The test substance formed a white solid pellet.

Exposing test substance to mechanical stress by friction did lead to a discolouration: the test substance decomposed into a black residue, probably caused by the released heat coming from the friction between the two porcelain surfaces. Sparks but no fire, smoke or crepitation were observed in each of the six tests. The sparks were probably caused by friction between the porcelain peg and plate and not by reaction of the test substance. Because no vigorous reaction was observed, the test substance should not be considered as explosive.

Applicant's summary and conclusion

Interpretation of results:
non explosive
Remarks:
Migrated information
Executive summary:

The test substance is not explosive when exposed to thermal stress.

The test substance is not explosive when exposed to mechanical stress by shock.

The test substance does react under mechanical stress by friction, but no vigorous reaction was observed.

The test substance should therefore not be considered as explosive.

Based on all results it is concluded that the test substance is not explosive when exposed to thermal stress or mechanical stress (shock and friction).

Categories Display