Registration Dossier
Registration Dossier
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EC number: 203-425-1 | CAS number: 106-70-7
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The chemical safety assessment according to Annex I of Regulation (EC) No. 1907/2006 does not indicate the need to investigate further the long-term toxicity to fish.
Key value for chemical safety assessment
Additional information
No data evaluating the chronic toxicity of methyl hexanoate (CAS No. 106-70-7) to fish species are available. According to Regulation (EC) No. 1907/2006, Annex IX, Column 2, 9.1.6, long-term toxicity testing shall be proposed by the registrant if the chemical safety assessment according to Annex I indicates the need to investigate further the effects on aquatic organisms. Based on the results of the acute tests performed on methyl hexanoate with species from three different trophic levels (fish, aquatic invertebrates and algae), fish was the species showing the least sensitivity. The study conducted on fish species showed a LC50 (48 h) value of 170 mg/L (nominal), whereas for aquatic invertebrates and algae EC50 values of 40 and 61 mg/L (nominal, respectively) were obtained, corresponding to mean measured concentrations of 28 mg/L and 11 mg/L.
On the other hand, a chronic NOEC (72 h) value of 12.5 mg/L was reported for algae (nominal, growth rate), corresponding to a mean measured concentration of 2.7 mg/L. A chronic test on aquatic invertebrates according to OECD 211 is currently ongoing (on a suitable read-across substance, methyl octanoate (CAS No. 111-11-5). The dossier will be updated as soon as possible and the chemical safety assessment according to Annex I of Regulation (EC) No. 1907/2006 will be re-evaluated based on the outcome of this new test.
Based on the acute values, aquatic invertebrates and algae are expected to show higher sensitivity compared to fish species (also observed in the rest of the substances of the SCAE Me category). Due to the existence of chronic values for both aquatic invertebrates (ongoing) and algae, and the higher sensitivity of these organisms compared to that of fish, additional chronic toxicity data on fish is not deemed necessary.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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