Registration Dossier
Registration Dossier
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EC number: 252-043-1 | CAS number: 34454-97-2
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
96-hour LC50 of C4 sulfonamido alcohol to Pimephales promelas: 25 mg/L (EPA 850.1075 and OECD 203). C4 glycine acid (stable biodegradation product) was not toxic to P. promelas to a limit of 100 mg/L.
Key value for chemical safety assessment
Additional information
C4 sulfonamido alcohol underwent primary biodegradation in an inherent biodegradability test, forming C4 glycine acid as a stable product. Accordingly, toxicity to fish was assessed for both C4 sulfonamido alcohol and C4 glycine acid. The acute toxicity of C4 sulfonamido alcohol to the freshwater fish Pimephales promelas was examined in a 96-hour static test based on EPA OPPTS 850.1075 and OECD 203, with analytical determination of concentrations. The test was GLP compliant and is considered reliable without restriction. In a supporting study, toxicity of C4 glycine acid to P. promelas was assessed in a static, limit test done according to OECD 203, with nominal concentrations only. The test solution was slightly cloudy throughout the test, indicating that test substance was not entirely soluble in the well water used to make up the test vessels. Nevertheless, no mortality or sublethal effects were observed for the C4 glycine acid in fish.
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